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Tibolone exerts progestagenic effects on human endometrial cancer cells.
2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Tibolone exerts progestagenic effects on human endometrial cancer cells.
"Tibolone, a synthetic steroid acting in a tissue-specific manner and used in hormone replacement therapy, is converted into three active metabolites: a Delta(4) isomer (exerting progestagenic and androgenic effects) and two hydroxy metabolites, 3alpha-hydroxytibolone (3alpha-OH-tibolone) and 3beta-OH-tibolone (exerting estrogenic effects)," scientists writing in the Journal of Clinical Endocrinology and Metabolism report.
"In the present study an endometrial carcinoma cell line (Ishikawa PRAB-36) was used to investigate the progestagenic properties of tibolone and its metabolites. This cell line contains progesterone receptors A and B, but lacks estrogen and androgen receptors," wrote L.J. Blok and colleagues, Erasmus Medical Center.
"When tibolone was added to the cells, complete conversion into the progestagenic/androgenic Delta(4) isomer was observed within 6 d. Furthermore, when cells were cultured with tibolone or when the Delta(4) isomer or the established progestagen medroxyprogesterone acetate was added to the medium, marked inhibition of growth was observed," the researchers wrote.
"Interestingly, 3beta-OH-tibolone also induces some inhibition of growth. These growth inhibitions were not observed in progesterone receptor-negative parental Ishikawa cells, ...
- Tibolone Stops Bone Loss, Reduces Hot Flashes.
- Magazine article from: OB GYN News MOON, MARY ANN September 15, 2001 700+ words
WASHINGTON -- The synthetic steroid tibolone is proving to prevent bone loss and to...symposium on women's health and menopause. Tibolone is not yet commercially available in...Organon Inc., West Orange, NJ. Tibolone has been studied extensively in the United...
- Tibolone Stops Bone Loss, Reduces Hot Flashes and Vaginal Dryness.(Brief...
- Magazine article from: Family Practice News MOON, MARY ANN September 1, 2001 700+ words
WASHINGTON -- The synthetic steroid tibolone is proving to prevent bone loss and to...symposium on women's health and menopause. Tibolone has been studied extensively in the United...Creighton University, Omaha, Neb. Tibolone is not yet commercially available in...
- Tibolone Fracture Trial.(Clinical report)
- Magazine article from: OB/GYN Clinical Alert October 1, 2008 700+ words
Tibolone Fracture Trial Abstract & Commentary...randomized clinical trial reported that tibolone reduced vertebral fractures by 45% and...Cummings SR, et al. The effects of tibolone in older postmenopausal women. New Engl...
- Tibolone cuts fractures, cancer, but ups stroke.(Metabolic Disorders)
- Magazine article from: Family Practice News Moon, Mary Ann September 15, 2008 700+ words
Tibolone reduced the risk of vertebral and nonvertebral fractures...associates in the Long-Term Intervention on Fractures with Tibolone (LIFT) study. [ILLUSTRATION OMITTED] Tibolone is approved for treating menopausal symptoms in 90 countries...
- Special Feature: The LIBERATE Tibolone Trial in Breast Cancer...
- Magazine article from: OB/GYN Clinical Alert April 1, 2009 700+ words
Special Feature The LIBERATE Tibolone Trial in Breast Cancer Survivors...was designed to demonstrate that tibolone was superior to placebo, but when...inhibitors (6.5%). The dose of tibolone was 2.5 mg daily. Final numbers...
- Important new monkey study from Tom Clarkson.(tibolone and atherosclerosis)
- Magazine article from: OB/GYN Clinical Alert January 1, 2002 700+ words
Synopsis: Tibolone treatment does not increase coronary...placebo response to high and low doses of tibolone, unopposed conjugated equine estrogens...medroxyprogesterone acetate. The daily doses of tibolone were equivalent to women's doses of...
- Tibolone and atherosclerosis.(Report)
- Magazine article from: OB/GYN Clinical Alert Speroff, Leon March 1, 2006 700+ words
Tibolone and Atherosclerosis Abstract & Commentary...GYN Clinical Alert. Synopsis: Both tibolone and CEE/MPA showed increased progression...Source: Bots ML, et al. The effect of tibolone and continuous combined conjugated equine...
- Tibolone increases bone density, lacks side effects: as effective as hormone...
- Magazine article from: Family Practice News Sullivan, Michele G. January 1, 2004 700+ words
...MIAMI BEACH -- The synthetic steroid tibolone appears to increase bone mineral density...the North American Menopause Society. Tibolone (Livial), marketed by Organon International...Osteoporosis Prevention and Arterial Effects of Tibolone study (OPAL), a 3-year randomized...
- Tibolone tied to increased BMD, less bleeding: not available in the United...
- Magazine article from: OB GYN News Sullivan, Michele G. November 1, 2003 700+ words
...MIAMI BEACH -- The synthetic steroid tibolone appears to increase bone mineral density...the North American Menopause Society. Tibolone (Livial), marketed by Organon International...Osteoporosis Prevention and Arterial Effects of Tibolone study (OPAL), a 3-year randomized...
- Tibolone relieves menopausal symptoms, prevents BMD loss at spine and femur.
- Newspaper article from: Drug Week June 4, 2004 700+ words
...net) -- A dose-comparison study of tibolone shows that even at lower doses, the...evaluate the effect of two doses of oral tibolone, 1.25 mg and 2.5 mg, on bone loss...women were assigned to receive 2.5 mg tibolone, another 30 received 1.25 mg, and...
Source: HighBeam Research, Tibolone exerts progestagenic effects on human endometrial cancer...