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Two forms of fibulin-1 protein are upregulated by malignant breast cancer tissue.
2003 JUL 3 - (NewsRx.com & NewsRx.net) -- There are different forms of fibulin-1 protein, and two types may be upregulated by breast cancer tissue.
"The extracellular matrix protein fibulin-1 suppresses the motility and invasiveness of a variety of tumor cell types in vitro as well as the growth of fibrosarcoma tumors in nude mice. In this study, fibulin-1 protein expression in breast carcinoma specimens and normal breast tissue was evaluated immunohistologically.
"Fibulin-1 protein expression was also semiquantitatively assessed by immunoblot analysis in a collection of normal breast tissues (n=18), benign tumors (n=5) and breast carcinomas (n=39)," researchers in Ireland report.
L.M. Greene and colleagues wrote, "In normal breast tissue, fibulin-1 protein expression predominated in the ductal epithelium and underlying myoepithelium, with weaker staining evident in the loose connective tissue surrounding the ducts. Examination of breast carcinomas revealed that the tumor cells also expressed fibulin-1 protein. The level of mature fibulin-1 polypeptide (100 kDa) was higher in the breast carcinoma specimens as compared to normal breast tissue (Mann-Whitney U-test, p=0.0005).
"In addition to the mature fibulin-1 peptide, several smaller sized proteins of 55, 50, and 25 kDa were detected using monoclonal antibodies reactive towards an epitope located at the N-terminus of fibulin-1. The immunoreactive 50 ...
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