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PTHrP expression is predictive of longer survival in breast cancer.
2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Higher parathyroid hormone-related peptide expression is predictive of longer survival in breast cancer patients.
"Parathyroid hormone-related peptide (PTHrP) participates in the development of humoral hypercalcemia of malignancy. The peptide is thought to affect growth and differentiation of normal and neoplastic cells. The present study aimed at evaluation of the relationship between survival time and development of distant metastases in patients with ductal mammary carcinoma on the one hand and PTHrP expression on the other," scientists writing in the journal Virchows Archiv report.
"Immunocytochemical reactions using mouse monoclonal (clone 212-10.7) anti-PTHrP (38-64) antibodies were performed in paraffin sections originating from 47 patients with ductal mammary carcinoma. Expression of the protein was quantified employing a scale considering the number of positive cells and intensity of the reaction (immunoreactive score, IRS).
"Survival time of the patients, determined during the course of a 7-yr observation was also analyzed. The obtained results demonstrated a relationship between intensity of PTHrP expression and the survival time," wrote P. Surowiak and colleagues.
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