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New chemotherapy agent highlighted in oncology studies.
2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Taxotere (docetaxel) Injection Concentrate, an active chemotherapy agent, showed positive results in various treatment regimens in early and advanced breast cancer according to numerous phase II and III clinical studies presented at the annual meeting of the American Society of Clinical Oncology (ASCO).
Among the studies involving Taxotere at this year's ASCO, several focused on the use of Taxotere to treat women with early stage breast cancer before (neoadjuvant) or after (adjuvant) surgery, as well as women with advanced disease.
Three-year results of a prospective, randomized trial of adjuvant therapy among patients with stage I-III operable, invasive breast cancer showed a 21% reduction in the risk of recurrence in patients given Taxotere and cyclophosphamide (TC) versus those given doxorubicin and cyclophosphamide (AC). At a median follow-up of 43 months, TC was also better tolerated than the standard AC adjuvant regimen.
The trial included 1,016 patients who were randomized to receive either four courses of the standard dose of AC, 60/600-mg/m[superscript]2, or four courses of TC, 75/600-mgs/m[superscript]2, each given every three weeks preceding adjuvant radiation therapy and tamoxifen if indicated.
Researchers from the Magee-Women's Hospital and the University of Pittsburgh Cancer Institute also reported phase II study results that showed the combination of Taxotere, carboplatin and traztuzumab (herceptin).
Forty previously untreated patients with MBC participated in this study. TCH was ...
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Source: HighBeam Research, New chemotherapy agent highlighted in oncology studies.