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Increased expression of the Bfl-1 gene may contribute to breast cancer.
2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Increased expression of the Bfl-1 gene may contribute to breast cancer.
"The Bfl-1 gene, which was isolated from human fetal liver and only recently described, is a member of the Bcl-2 gene family. Reverse transcriptase-polymerase chain reaction was performed on RNA drawn from 30 breast cancer tissues to compare the expression of the Bfl-1 gene with other prognostic factors," scientists in South Korea report.
"The median relative ratio was 3.0 (range, 0.12-26.83) and the Bfl-1 gene expression rate was 36.7% (11/30). There was no statistically significant, relationship between the clinicopathologic parameters of patients and the expression value of Bfl-1 gene," wrote H.S. Yoon and colleagues, University of Ulsan College of Medicine.
"The level of Bfl-1 gene expression was higher in more advanced breast cancers than in early cancers," the researchers wrote.
The researchers concluded: "There was no significant relationship between the expression values and currently acknowledged prognostic factors, but a higher expression pattern was noticed ...
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