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Careful standardization needed for multicenter breast cancer genetic screening.
2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Careful standardization is necessary for multicenter genetic screening.
"Epidemiologic studies of breast and other cancers are increasingly turning toward large, multicenter designs in order to obtain adequate power to detect low-penetrance susceptibility alleles," researchers in the United States report.
"The size of such studies often makes it necessary to distribute the genetic screening efforts to multiple sites. Careful standardization of screening methodology and quality control across sites is required for such multicenter screening designs to be efficient," wrote J.L. Bernstein and colleagues, Mt Sinai School of Medicine, Department of Community & Preventive Medicine.
The researchers concluded: "In this report, we illustrate our approach to these challenges in the context of the WECARE (Women's Environment, Cancer and Radiation Epidemiology) Study, a multicenter population-based genetic epidemiologic study of women with unilateral and bilateral breast cancer.
"We provide ...
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