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Antioxidants and vitamins may reduce estrogen-associated breast cancer risk.
2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Antioxidants and vitamins may reduce estrogen-associated breast cancer risk.
"Modulation of the cytotoxicity and mutagenicity of 4-hydroxyestradiol (4-OHE2), an oxidative metabolite of estrogen, by antioxidants was assessed in human MCF7 cells and TK-6 lymphoblast cells," scientists writing in the journal Proceedings of the National Academy of Sciences USA report.
"The cytotoxicity of the catecholic estrogens was potentiated by depletion of intracellular glutathione and was independent of oxygen concentration. Agents such as the nitroxide Tempol can facilitate the oxidation of the semiquinone to the Q and enhanced 4-OHE2 cytoxicity," wrote A.M. Samuni and colleagues, NCI, Cancer Research Center.
"Conversely, reducing agents such as ascorbate, cysteine, and 1,4-dihydroxytetramethylpiperidine (THP) protected against cytotoxicity and decreased mutation induction, presumably by reducing the semiquinone to the hydroquinone," the researchers stated.
The researchers concluded: "Our results support the proposition that oxidation of the semiquinone to the corresponding Q is crucial in eliciting the deleterious effects of catecholic estrogens. ...
- Hybridon Identifies Novel Synthetic Immunostimulatory Motif in Oligonucleotides...
- Press release article from: PR Newswire December 2, 2003 700+ words
...overrides species- specific recognition observed with CpG motif" in the recent issue of Proceedings of the National Academy of Sciences USA (vol. 100, pp 14303- 14308). Studies previously published by others have shown that oligonucleotides...
- ALEXION Complement Inhibitor Reduces Lupus-Like Autoimmune Disease; Study...
- Press release article from: PR Newswire August 6, 1996 700+ words
...significant amelioration of lupus-like autoimmune disease in animals. Published in today's issue of "Proceedings of the National Academy of Sciences," the study provides new evidence that the Company's C5 inhibitors may be a novel class of potent therapeutics...
- Report in Proceedings of the National Academy of Sciences documents key immune...
- Press release article from: PR Newswire September 17, 1990 700+ words
REPORT IN PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES DOCUMENTS KEY IMMUNE RESPONSES...in today's issue of the Proceedings of the National Academy of Sciences (USA) ("PNAS") that the HGP-30 AIDS vaccine...
- Compugen Announces In-Silico Protein Discovery from ''Junk DNA''; Findings...
- Press release article from: Business Wire February 14, 2006 700+ words
...several previously unknown therapeutic protein candidates and has been published in Proceedings of the National Academy of Sciences (USA) (Shemesh et al. PNAS, January 31 2006). The DNA sequences utilized by the new methodology are essentially...
- ImmunoGen Drug Eradicates Large Human Colon Tumors in Mice Without Harmful Side...
- Press release article from: PR Newswire August 6, 1996 700+ words
...well below those that produce toxic side effects. The studies, published today in the Proceedings of the National Academy of Sciences USA (PNAS), suggest that the drug, called C242-DM1, represents a promising new approach to the treatment...
- Antioxidant Found in Broccoli and Broccoli Sprouts Protects Eyes From Light...
- Press release article from: PR Newswire July 13, 2004 700+ words
...Proceedings of the National Academy of Sciences USA, May 4, 2004...Proceedings of the National Academy of Sciences USA, Vol. 101, pp...Proceedings of the National Academy of Sciences USA, Vol. 99, pp...
- Novel RNase cancer drug shows promise for AIDS; ONCONASE inhibits the HIV virus.
- Press release article from: Business Wire August 26, 1996 700+ words
...findings further confirm our previously published observations regarding acutely infected cells (Proceedings National Academy Sciences USA 91:6012-6016, 1994). We are particularly encouraged by the prospects of the clinical applications...
- Paracellular chloride permeability is regulated by WNK4 kinase.
- Newspaper article from: Obesity, Fitness & Wellness Week January 1, 2005 700+ words
...Proceedings of the National Academy of Sciences USA, paracellular chloride...Proceedings of the National Academy of Sciences USA (Paracellular Cl...Proceedings of the National Academy of Sciences USA is: National Academy...
