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Test identifies patients at high risk of bone complications.
2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Data show that the bone marker N-telopeptide (Ntx) may predict the clinical outcome of patients with bone complications that stem from a variety of different cancers, according to a study presented at the American Society of Clinical Oncology (ASCO) meeting in Chicago, Illinois.
These results demonstrate the potential role the bone marker may have in providing an early warning of potential skeletal complications and need for treatment of bone metastases, providing physicians a powerful tool in patient management. The analysis included data from three major clinical trials evaluating zoledronic acid in more than 3,000 patients who suffer from a broad range of tumor types, such as breast, prostate, lung and other solid tumors and multiple myeloma.
The data from these studies are the most extensive available and present an unprecedented opportunity to analyze the predictive roles of bone markers for subsequent skeletal complications.
Research indicates that many patients with advanced cancers will develop bone metastasis, the spread of cancerous cells from the original tumor to bones. Often, bone is the only site of metastasis in these patients. Complications resulting from bone metastases include, among others, bone pain, pathologic fractures, a need for radiation or surgery to bone, spinal cord compression, and change of antineoplastic therapy to treat bone pain and hypercalcemia.
"Bone metastases and their complications can be severely debilitating for advanced cancer patients with a highly negative ...
- Data Demonstrate the Predictive Role of Bone Marker in Identifying Patients At...
- Press release article from: PR Newswire June 2, 2003 700+ words
...telopeptide (Ntx) may predict...patients with bone complications that stem...studied, Ntx most consistently predicted bone complications, disease...concentration of Ntx increases...relative risk of bone complications, disease...
- Data demonstrates the predictive role of bone marker in identifying patients at...
- Press release article from: PR Newswire June 2, 2003 700+ words
...telopeptide (Ntx) may predict...patients with bone complications that stem...studied, Ntx most consistently predicted bone complications, disease...concentration of Ntx increases...relative risk of bone complications, disease...
- Test identifies patients at high risk of bone complications.
- Newspaper article from: Drug Week July 4, 2003 700+ words
...telopeptide (Ntx) may predict...patients with bone complications that stem...studied, Ntx most consistently predicted bone complications, disease...concentration of Ntx increases...relative risk of bone complications, disease...
- Novartis' Zometa offers advance in bone complications of kidney cancer.
- Newspaper article from: Pharma Marketletter March 24, 2003 700+ words
...cell carcinoma will develop bone complications during the course of their...treatment, the company notes. "Bone complications from kidney cancer can be...efficacy in prevention of bone complications across a broad range of tumor...
- Data: Bone complications lead to increased medical care costs.
- Newspaper article from: Blood Weekly June 26, 2003 700+ words
...com & NewsRx.net) -- Bone complications associated with multiple myeloma...experience bone pain. "We suspected that bone complications add substantially to the cost of...patients in the U.S. incur due to bone complications, or skeletal-related events...
- New Long-term Data Show ZOMETA(R) Slows Pain Progression and Reduces Bone...
- Press release article from: PR Newswire April 29, 2003 700+ words
...significantly lowers the risk of debilitating bone complications and delays their onset by a median...demonstrate ZOMETA may reduce the risk of bone complications and their pain progression. The...medication during an extension phase. Bone Complications After 24 months of treatment, ...
- New data demonstrate that bone complications lead to increased costs.
- Newspaper article from: Blood Weekly June 19, 2003 700+ words
...com & NewsRx.net) -- Bone complications associated with multiple myeloma...experience bone pain. "We suspected that bone complications add substantially to the cost of...patients in the U.S. incur due to bone complications, or skeletal-related events...
- New Data Demonstrate That Bone Complications Common to Multiple Myeloma Lead To...
- Press release article from: PR Newswire May 24, 2003 700+ words
...Spain, May 24 /PRNewswire/ -- Bone complications associated with multiple myeloma...experience bone pain. "We suspected that bone complications add substantially to the cost of...patients in the U.S. incur due to bone complications, or skeletal-related events...