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Primary ovarian cancer spheroids host replicative adenovirus targeting integrin.
2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Primary ovarian cancer spheroids host replicative adenovirus targeting integrin.
According to a study from Finland, "replication competent viruses hold promise for treatment of advanced cancers resistant to available therapeutic modalities. Although preliminary clinical results have substantiated their efficacy, preclinical development of these novel approaches is limited by assay substrates. The evaluation of candidate agents could be confounded by differences between primary tumor cells and tumor cell lines, as discordance in the levels of surface receptors relevant for viral entry has been reported."
"Since primary tumor cells are difficult to analyze ex vivo for longitudinal observation of virus replication, we developed three-dimensional aggregates or spheroids of unpassaged and purified ovarian cancer cells as a means for prolonging primary tumor cell viability and as a three-dimensional in vitro model for replicative viral infection," said J.T. Lam and colleagues, University of Helsinki.
"Ovarian cancer cells purified from ascites samples were sustained for 30 days while retaining the infection profile with tropism modified and unmodified ...
- Infectivity-enhanced adenoviral vectors guide ovarian cancer gene therapy.
- Newspaper article from: Gene Therapy Weekly July 8, 2004 700+ words
...adenoviral vectors guide ovarian cancer gene therapy. "Ovarian carcinoma...for their utility in ovarian cancer gene therapy using in vitro and in...may be very useful in ovarian cancer gene therapy," researchers proposed...
- Gene Therapy Shows Promise for Early-Stage Ovarian Cancer.(Brief Article)
- Magazine article from: Family Practice News JOHNSON, KATE April 15, 2001 700+ words
...with newly diagnosed ovarian cancer may be eligible for gene therapy to treat their disease...Until now, only ovarian cancer patients who had failed...to assess different gene therapy strategies for ovarian cancer, he said. Dr. Buller...
- BRCA1 Gene Therapy Trials for Ovarian Cancer Reopened.(Brief Article)
- Magazine article from: Family Practice News JOHNSON, KATE September 1, 2000 700+ words
...trials of BRCA1 gene therapy for ovarian cancer have reopened after...that the goal of gene therapy is to inject the...BRCA1 gene into ovarian cancer cells, researchers...retroviral BRCA1 gene therapy via a peritoneal...
- Adenovirus-mediated suicide gene therapy destroys ovarian cancer cells.
- Newspaper article from: Cancer Gene Therapy Week January 19, 2004 700+ words
...mediated suicide gene therapy destroys ovarian cancer cells. "Telomerase...gynecological cancer gene therapy," they concluded...mediated suicide gene therapy using the human...induced apoptosis of ovarian cancer cell line. Biosci...
- CELLPRO TO PLAY KEY ROLE IN GENE THERAPY TRIAL FOR OVARIAN CANCER AT M.D....
- Press release article from: PR Newswire June 8, 1993 700+ words
...Concentration System would be used in a gene therapy trial for ovarian cancer conducted by investigators at M.D...Anderson Cancer Center to perform this gene therapy for advanced ovarian cancer. Dr. Albert B. Deisseroth, chairman...
- Gene therapy for breast, ovarian cancer.(Brief Article)
- Magazine article from: Science News Fackelmann, Kathleen April 11, 1998 700+ words
A novel gene therapy technique may one day hold out promise for women with breast or ovarian cancer. Naoto T. Ueno of the University of...used the E1A gene to treat mice with ovarian cancer. The Texas team recruited 12 people...
- CELLPRO TECHNOLOGY USED IN NOVEL GENE THERAPY TRIAL; Multidrug Resistance Gene...
- Press release article from: Business Wire February 1, 1995 700+ words
...marrow of advanced ovarian cancer patients in a Phase...focused on advanced ovarian cancer patients who do not...this experimental gene therapy in other diseases...tool for research in gene therapy. The System first...
- Research on ovarian cancer therapy published by scientists at University of...
- Newspaper article from: Gene Therapy Weekly November 5, 2009 700+ words
...Republic of China, Ovarian Cancer Therapy, Biotechnology...Epithelial Carcinoma, Gene Therapy, Gynecology, Luciferase, Oncology, Ovarian Cancer, Ovarian Carcinoma...article was prepared by Gene Therapy Weekly editors from...
Source: HighBeam Research, Primary ovarian cancer spheroids host replicative adenovirus...