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ETS-1 expression is related to angiogenesis during the menstrual cycle.

Women's Health Weekly

| July 03, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 JUL 3 - (NewsRx.com & NewsRx.net) -- ETS-1 transcription factor expression is related to endometrial angiogenesis during the menstrual cycle.

According to published research from Japan, "ETS-1 has been identified as a transcription factor for angiogenesis, which is essential for the development and growth of the uterine endometrium. This characteristic prompted us to study whether ETS-1 functions as an angiogenic mediator in uterine endometrium. Immunohistochemical staining revealed that the localization of ETS-1 was similar to that of vascular endothelial cells."

"There was a significant correlation between microvessel counts and both ETS-1 histoscores and ets-1 mRNA levels in uterine endometrium. The ETS-1 histoscores and ets-1 mRNA levels increased in the proliferative phase, reached a peak during peri-ovulation and decreased in the secretory phase," described J. Fujimoto and colleagues, Gifu University, School of Medicine.

"Furthermore, the ETS-1 histoscores and ...

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