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Low efficacy of Rubini mumps vaccine strain leads to outbreak in Singapore.
2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Hemagglutinin-neuraminidase sequence and phylogenetic analyses were conducted on mumps virus isolates from a vaccinated population in Singapore.
According to recent research published in the Journal of Medical Virology, "During 1999-2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini vaccine strain. To explain this phenomenon, the complete nucleotide and amino acid sequences of the hemagglutinin-neuraminidase (HN) gene of eight mumps virus isolates from patients with parotitis in Singapore were determined and compared with those of known vaccine strains."
"Phylogenetic trees constructed on the basis of HN nucleotide and amino acid sequences showed that the Singapore mumps virus isolates were more closely related to the Urabe strain and belonged to a different cluster from the Rubini and Jeryl-Lynn strains," reported C. S. Lim and collaborators at the National University of Singapore. "The Rubini vaccine showed only approximately 93% nucleotide and approximately 96% amino acid sequence similarity to Urabe and Singapore isolates. Compared with the vaccine strains, six of the eight isolates lacked the extracellular glycosylation site at residues 400-402. Other significant amino acid disparities ...
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Source: HighBeam Research, Low efficacy of Rubini mumps vaccine strain leads to outbreak in...