Measles antibodies interfere with immune response in revaccinated adults.

2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Measles-specific antibodies interfere with the humoral immune response in adults re-immunized with measles vaccine.

According to published research from Mexico, "The objective of this study was to characterize the kinetics' of the cellular and humoral immune responses elicited by measles vaccine given to previously immune adults."

"The cellular and humoral immune responses to measles were measured in seven healthy adults, before vaccination and at 1, 2, 3, and 4 weeks and 3 months after vaccination, using measles-specific T-cell proliferation and plaque reduction neutralization assays," reported Rosa Maria Wong-Chew and colleagues at the Universidad Nacional Autonoma de Mexico in Mexico City and the U. S. Food and Drug Administration. "All study subjects had detectable measles antibodies, but only six (85%) showed protective titers, defined as >1:120, before immunization. However measles-specific T-cell proliferation was not detectable before vaccination in any of the subjects."

The researchers found, "The six subjects with protective titers showed a positive stimulation index (SI) of >3.0 within the first four weeks after vaccination, an SI of 5 at the fourth week, and an SI of 3 at three months after vaccination. The subject with a low antibody titer (1:99) before vaccination developed a high SI at three months after vaccination. This subject was the only ...