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DNA immunization effective against MRSA.
2003 JUL 2 - (NewsRx.com & NewsRx.net) -- A novel DNA vaccine may provide protection against methicillin-resistant Staphylococcus aureus (MRSA), researchers in Brazil report.
MRSA is "a major pathogen responsible for serious hospital infections worldwide," explained Jose P.M. Senna and colleagues at the Universidade Federal do Rio Grande do Sul and the Pontificia Universidade Catolica do Rio Grande do Sul. "These bacteria are resistant to all beta-lactam antibiotics due to the production of an additional penicillin binding protein, the PBP2a, encoded by the mecA gene, which shows low affinity for this class of antibiotics."
A vaccine based on the PBP2a protein elicited robust immune activity against MRSA in mice, Senna and coauthors found.
The researchers immunized mice with a mammalian vector expressing part of PBP2a's transpeptidase domain. Significant anti-MRSA humoral activity was seen after treatment, they said.
Study animals were challenged with sublethal doses of MRSA after immunization. The bacterial load in kidneys from vaccinated mice was 1000 times lower than the bacterial load in kidneys from control mice, according to the report.
The vaccine did not trigger ...
- DNA immunization effective against MRSA.
- Newspaper article from: Proteomics Weekly June 30, 2003 700+ words
...Staphylococcus aureus (MRSA), researchers in Brazil report. MRSA is "a major pathogen...Universidade Federal do Rio Grande do Sul and the Pontificia...Universidade Federal do Rio Grande do Sul, Cx.Postal...Staphylococcus aureus (MRSA) infection 2) This...
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...held by the Red, the Sabine, and the Rio Grande. Each is a distinct river. The Red...Sabine is dark and forested, and the Rio Grande is nearly gone. It is startling to discover...history was written on the banks of the Rio Grande. It is the mother river of Texas, the...
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- News wire article from: US Fed News Service, Including US State News November 6, 2009 700+ words
RIO GRANDE, Ohio, Nov. 4 -- Rio Grande Community College issued the following news release: The University of Rio Grande/Rio Grande Community College has once again been named a "Champions Of Character" institution by the National Association...
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- Newspaper article from: Life Science Weekly June 2, 2003 700+ words
...economic analysis of the cost to keep the Rio Grande flowing for the endangered silvery minnow...agriculture and water users for the upper Rio Grande Basin," said Ward, who conducted a...simulation of future water inflows. The upper Rio Grande Basin covers an area from southern ...
