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Systemic priming with mucosal boosting shows promise in animals.
2003 JUL 2 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Vaccine researchers in the United States say that a mixture of systemic and mucosal immunization may offer improved protection against HIV infection.
"Although most HIV-1 infections worldwide result from heterosexual transmission, most vaccine candidates have focused on induction of systemic immunity and protection," explained Zandrea Ambrose and colleagues at the University of Washington in Seattle, Tulane University in New Orleans, Duke University in Durham, North Carolina, and Therion Biologics in Cambridge, Massachusetts.
A vaccine regimen combining systemic priming and mucosal boosting produced effective mucosal protection against vaginal infection in animals, Ambrose and coauthors found.
The researchers compared cellular and humoral immune responses in two groups of macaques primed systemically with a recombinant vaccinia virus-based vaccine. The treatment group received a mucosal boost with an inactivated form of the highly virulent simian-HIV hybrid SHIV89.6 plus adjuvant, they said, while control animals received only adjuvanted protein boosts.
Virus-specific T-cell activity was only seen ...
- Viral replication reduced in macaques mucosally immunized with...
- Newspaper article from: AIDS Vaccine Week June 16, 2003 700+ words
...candidates have focused on induction of systemic immunity and protection. We hypothesized that combining systemic priming with mucosal boosting would induce mucosal immunity that would protect from intravaginal challenge," scientists in the United...
- Findings For Bovine Trichomoniasis Vaccine May Be Applicable To Humans.
- Newspaper article from: Immunotherapy Weekly Saltmarsh, N.R. July 25, 2001 700+ words
...2001;45(5):310-319). "Systemic immunization or systemic priming with local boosting protects against bovine trichomoniasis...Uterine and vaginal IgA responses could be induced by systemic priming and local boosting via either the vaginal or nasal mucosa...
- Findings For Bovine Trichomoniasis Vaccine May Be Applicable To Humans.(Brief...
- Newspaper article from: Vaccine Weekly July 25, 2001 700+ words
...2001;45(5):310-319). "Systemic immunization or systemic priming with local boosting protects against bovine trichomoniasis...Uterine and vaginal IgA responses could be induced by systemic priming and local boosting via either the vaginal or nasal mucosa...
- Vaccine Delivery "Effects of the Nature of Adjuvant and Site of Parenteral...
- Newspaper article from: Vaccine Weekly October 19, 1998 700+ words
...local response (same isotypes) was measured in the salivary glands after the mucosal boost by ELISPOTs. We observed that systemic priming at any of the two sites with a Th2 rather than a Th1 adjuvant dramatically enhanced the mucosal IgG1 and IgA responses...