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Apoptosis plus CD80 costimulation promote immune response by melanoma cells.
2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Apoptotic cell death in conjunction with CD80 costimulation conferred uveal melanoma cells with the ability to induce immune responses.
"Uveal melanoma is a rare malignancy with a poor prognosis despite current therapeutic intervention. The current investigation focuses on the immunogenicity of uveal melanoma cells genetically modified with recombinant adenovirus encoding CD80 (AdCD80) in contrast to their parental counterpart. We demonstrate that costimulation provided by uveal melanoma cells improved immune responses in vitro as determined by mixed lymphocyte tumor cell cultures and cytotoxic T-cell assays using lymphocytes from healthy donors and uveal melanoma patients," researchers in England report.
"Flow cytometry revealed T-cell stimulation by activated CD4+ and CD8+ T cells," stated Jennifer Carlring and collaborators at the University of Sheffield. "Additionally, autologous lymphocytes proliferated in response to CD80-expressing primary uveal melanomas, indicating that this patient group is suitable for immunotherapy. Moreover, this study utilized AdCD80 modified and parental apoptotic tumor cells, loaded onto immature dendritic cells, as a source of tumor antigen. The ability of live or apoptotic tumor cells to stimulate lymphocyte ...
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...cancer in humans - specifically, uveal melanoma - and the silencing of GNAQ...about 50% of patients with uveal melanoma. In these patients, the mutation...siRNAs targeting GNAQ in human uveal melanoma cells demonstrated about 70% silencing...
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...investigate the association between posterior uveal melanoma and iris freckles, iris naevi, and...study of 65 patients with posterior uveal melanoma and 218 controls. Iris colour, iris...detect an association between posterior uveal melanoma and iris freckles, iris naevi, or...
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...choroidal pigmentation and posterior uveal melanoma. Methods: Cross sectional study of...consecutive patients diagnosed with posterior uveal melanoma (melanoma group) and 218 consecutive...factor for the development of posterior uveal melanoma in white patients. This finding may...
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...Background: Improved local treatment of uveal melanoma makes it possible for many patients...consistently reported to be absent in uveal melanoma. Novel anti-VEGF therapies are now...source of VEGF within eyes harbouring uveal melanoma is not clear, these data suggest that...
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...Abstract Backgroundlaims--Posterior uveal melanoma is the most common intraocular tumour...tumour. To study their involvement in uveal melanoma we analysed the expression of the...seven of 10 secreted MMP-9. Among uveal melanoma, invasion levels of 4-25% were...
Source: HighBeam Research, Apoptosis plus CD80 costimulation promote immune response by melanoma...