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Cytomegalovirus-specific T cells stimulated using modified dendritic cells.
2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Ex vivo stimulation of cytomegalovirus (CMV)-specific T cells was accomplished using CMV pp65-modified dendritic cells as stimulators.
"Cytomegalovirus (CMV) infection is a dangerous complication in immunosuppressed individuals such as allogeneic stem cell transplant patients. CMV disease can be prevented by the early post-transplant transfer of donor-derived, CMV-directed, T cells. Fast and cost efficient methods to generate CMV-specific T cells are, therefore, warranted," scientists in Sweden report.
"The current study utilized peptide-pulsed and adenovirus-transduced dendritic cells (DC) to generate CMV-restricted T cells," stated Bjorn Carlsson and colleagues at the University of Uppsala. "After one stimulation with CMV pp65[subscript]495-503 peptide-pulsed DC and three re-stimulations with peptide-pulsed monocytes, virtually all T cells were CD8+, expressed the relevant T cell receptor, and exhibited high peptide-specific lytic activity. After only one stimulation, pp65[subscript]495-503-restricted T cells could be sorted to a purity of higher than 95% and expanded up to 1000-fold in 2 weeks. This technique may prove useful for the rapid generation of large quantities of specific cytolytic T lymphocytes (CTL) for cell therapy."
"DC transduced with an adenoviral vector encoding the full-length pp65 ...
- Human CMV infection of monocytes alter monocyte function, differentiation to...
- Newspaper article from: Immunotherapy Weekly December 17, 2003 700+ words
...and are unable to differentiate into dendritic cells, researchers say. HCMV "infections...monocytes, which can differentiate into dendritic cells upon cytokine stimulation, play a...functionally active CD1a-positive dendritic cells, which exhibited severely depressed...
- Cytomegalovirus-specific T cells stimulated using modified dendritic cells.
- Newspaper article from: Drug Week July 4, 2003 700+ words
...cells was accomplished using CMV pp65-modified dendritic cells as stimulators. "Cytomegalovirus (CMV) infection is a dangerous complication...CMV)-specific T cells using CMV pp65-modified dendritic cells as stimulators. Br J Haematol...
- Cancer Vaccines "Gene Transfer in Dendritic Cells, Induced by Oral DNA...
- Newspaper article from: Vaccine Weekly December 14, 1998 700+ words
...immediate early promoter of cytomegalovirus (CMV). We tested whether orally administered...under the control of either the eukariotic CMV or a prokaryotic promoter. Using cytofluorometric...macrophages and CD11c(bright) dendritic cells (DCs) were scored as positive for GFP...
- Dendritic cells tied to psoriasis.(News)
- Magazine article from: Skin & Allergy News McNamara, Damian March 1, 2006 700+ words
...FLA. -- Recent research implicates dendritic cells in the pathogenesis of psoriasis and...promise by halting cytokines produced by dendritic cells, he noted. Psoriasis is widely known...published since 2003) suggest that dendritic cells also play a role. Researchers believe...
- IL-10-treated dendritic cells may induce GVHD risk.
- Newspaper article from: Blood Weekly May 6, 2004 700+ words
...amp; NewsRx.net) -- Dendritic cells treated with interleukin...IL-10-treated immature dendritic cells in the first mixed leukocyte...were cultured with mature dendritic cells of the same origin as IL...
- Dendritic cells heterogeneity and its role in cancer immunity.(Review Article)
- Magazine article from: Journal of Cancer Research and Therapeutics Kah-Wai, Lin Jacek, Tabarkiewicz Jacek, Rolinski April 1, 2006 700+ words
...Tabarkiewicz. Jacek, Rolinski. Jacek Dendritic cells are the most potent 'professional...primary immune response initiation. Dendritic cells originate from bone marrow progenitors...subsequently give rise to immature dendritic cells, which reside in peripheral tissues...
- FLT3 LIGAND STIMULATES GROWTH OF DENDRITIC CELLS
- Press release article from: PR Newswire November 30, 1995 700+ words
...been shown to promote the growth of dendritic cells, a formerly elusive type of cell...now, research into the utility of dendritic cells has been hampered because these cells...large numbers of functionally mature dendritic cells. "Dendritic cells could be quite...
- Nonprimed dendritic cells enhance immune response.(Brief Article)
- Newspaper article from: Vaccine Weekly June 19, 2002 700+ words
...writer - The addition of nonprimed dendritic cells to the same site targeted by the MUC1...researchers isolated activated nonprimed dendritic cells from syngeneic mice. Tumor growth...survival time was extended when the dendritic cells were simultaneously delivered to the...