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Antitumor immunity induced by electrofusion of tumor and dendritic cells.
2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Specific antitumor immunity was induced in mice with the electrofusion product of tumor cells and dendritic cells.
According to a study from the United States, "Dendritic cells (DCs) are potent antigen-presenting cells capable of inducing primary T-cell responses. Several immunotherapy treatment strategies involve manipulation of DCs, both in vivo and ex vivo, to promote the immunogenic presentation of tumor-associated antigens. In this study, an electrofusion protocol was developed to induce fusion between tumor cells and allogeneic bone marrow-derived DCs."
"Pre-immunization with irradiated electrofusion product was found to provide partial to complete protection from tumor challenge in the murine Renca renal cell carcinoma model and the B16 and M3 melanoma models," stated William M. Siders and colleagues at Genzyme Corporation. "Vaccinated survivors developed specific immunological memory and were able to reject a subsequent rechallenge with the same tumor cells but not a syngeneic unrelated tumor line. Antitumor protection in the B16 model was accompanied by the development of a polyclonal cytotoxic T-lymphocyte response against defined melanoma-associated antigens. The therapeutic potential of this type of approach was suggested by the ...
- Stressed apoptotic tumor cells stimulate dendritic cells and induce cytotoxic T...
- Newspaper article from: Cancer Weekly January 28, 2003 700+ words
...apoptotic tumor cells, we analyzed...responses of dendritic cells to these...apoptotic tumor cells are capable...maturation of dendritic cells and, ultimately...apoptotic tumor cells stimulate dendritic cells and induce...
- Stressed apoptotic tumor cells stimulate dendritic cells and induce cytotoxic T...
- Newspaper article from: Vaccine Weekly January 29, 2003 700+ words
...apoptotic tumor cells, we analyzed...responses of dendritic cells to these...apoptotic tumor cells are capable...maturation of dendritic cells and, ultimately...apoptotic tumor cells stimulate dendritic cells and induce...
- Dendritic cells with apoptotic tumor cells induce strong T-cell response.
- Newspaper article from: Cancer Weekly July 15, 2003 700+ words
...amp; NewsRx.net) -- Dendritic cells loaded with apoptotic tumor cells induce a stronger T-cell...tumor hybrids in B-CLL. "Dendritic cells (DC) are professional...capture antigen from apoptotic tumor cells and induce MHC class I...
- Dendritic cells that capture dead tumor cells secrete IL-12 and TNF-alpha.
- Newspaper article from: Health & Medicine Week December 27, 2004 700+ words
...Monocyte-derived dendritic cells that capture dead tumor cells secrete IL...monocyte-derived dendritic cells (Mo-DCs) that capture dead tumor cells (Mo-DCs...Monocyte-derived dendritic cells that capture dead tumor cells secrete IL...
- Adoptive Transfer of Immature Dendritic Cells with Autologous or Allogeneic...
- Newspaper article from: Immunotherapy Weekly August 9, 1999 700+ words
...R.G. "Adoptive Transfer of Immature Dendritic Cells with Autologous or Allogeneic Tumor Cells Generates Systemic Antitumor Immunity...article published in Cancer Research, "Dendritic cells (DCs) are potent antigen-presenting...
- Method of loading antigen onto dendritic cells affects immune response.
- Newspaper article from: Vaccine Weekly October 16, 2002 700+ words
...cell lysates. "Dendritic cells (DC) have been...with lysed whole tumor cells. The in vitro studies...the search term "dendritic cells" yielded over 132...against leukemia tumor cells * Dendritic cells pulsed with apoptotic...
- Antitumor immunity induced by electrofusion of tumor and dendritic cells.
- Newspaper article from: Cancer Vaccine Week June 30, 2003 700+ words
...electrofusion product of tumor cells and dendritic cells. According to...United States, "Dendritic cells (DCs) are potent...fusion between tumor cells and allogeneic...electrofusion product of tumor cells and dendritic cells. Mol Ther, 2003...
- Vaccine Research Results Show Hope For Use Of Dendritic Cells.(Brief Article)
- Newspaper article from: Vaccine Weekly April 11, 2001 700+ words
...inside of tumor cells, to be released...the child's dendritic cells. The protein...activates the dendritic cells, allowing them...ultimately the tumor cells - in the patients...The activated dendritic cells are then injected...