AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Interleukins-2 and -4, but not interferon-gamma, exhibit adjuvant activity.
2003 JUL 2 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Interleukin-2 and interleukin-4 act provide adjuvant activity for herpes simplex virus vaccines, in contrast to interferon-gamma, which does not enhance vaccine potency, according to a report in the Journal of Virology.
"The adjuvant effects of cytokines in humoral and cell-mediated immunity to herpes simplex virus type 1 (HSV-1) have been examined in mice using HSV-1 recombinant viruses expressing murine interleukin-2 (IL-2), IL-4, or gamma interferon (IFN-gamma) gene," reported Yanira Osorio and Homayon Ghiasi at the University of California-Los Angeles.
The researchers immunized BALB/c mice one or three times with control virus or HSV-1 viruses expressing IL-2, Il-4, or IFN-gamma.
"Despite similar replication kinetics, these three recombinant viruses elicited different immune responses to HSV-1 on immunization," stated Osorio and Ghiasi.
The vaccine utilizing IL-4 expression stimulated a stronger antibody response compared to vaccines incorporating the control virus or those expressing IL-2 or IFN-gamma. However, the cytotoxic T lymphocyte response was greater with the IL-2 vaccine compared to the vaccines expressing IL-4 or IFN-gamma.
In vitro experiments using splenocytes from mice immunized with inactivated HSV-1 revealed that a T[subscript]H1 mechanism operated for all of the recombinant virus vaccines.
"As observed for the parental virus, both CD4+ and CD8+ T cells contributed equally to the production of IL-2 by the splenocytes of mice immunized with any of the three recombinant viruses," said the investigators. "However, the pattern ...
- IL-12 combined with BEN vs HSV-1 after thermal injury has therapeutic effect.
- Newspaper article from: Immunotherapy Weekly April 9, 2003 700+ words
...NewsRx.net) -- IL-12 combined with BEN vs HSV-1 after thermal injury...TI-mice exposed to HSV-1 survived after they received IL-12 and BEN or BEN...TI-mice exposed to HSV-1 and treated with either IL-12, BEN or BEN-CD4...
- IL-12 combined with BEN vs HSV-1 after thermal injury has therapeutic...
- Newspaper article from: Virus Weekly April 8, 2003 700+ words
...NewsRx.net) -- IL-12 combined with BEN vs HSV-1 after thermal injury...TI-mice exposed to HSV-1 survived after they received IL-12 and BEN or BEN...TI-mice exposed to HSV-1 and treated with either IL-12, BEN or BEN-CD4...
- Cytotoxic T cells inactivated by HSV-infected cells.
- Newspaper article from: Biotech Week April 28, 2004 700+ words
...inactivated CTL are not infected with HSV," noted D.D. Sloan and colleagues...when the CTL are removed from the HSV-infected cells. "IL-2 treatment does not alter inactivation...indicated. "CTL inactivated by HSV-infected cells are not apoptotic...
- Intrauterine HSV-2 infection is linked to neonatal lower-limb hypoplasia.
- Newspaper article from: Drug Week May 21, 2004 700+ words
...herpes simplex virus type 2 (HSV-2) infection was established...patient with in utero-acquired HSV-2 infection presenting with...varicella-zoster syndrome, HSV-2 infection should also be...1427 E 60TH St., Chicago, IL 60637-2954 USA. The information...
- HSV-1 gingivostomatitis in last 2 trimesters of pregnancy doesn't harm fetus.
- Newspaper article from: Health & Medicine Week May 31, 2004 700+ words
...Primary herpes simplex virus type 1 (HSV-1) gingivostomatitis causes oral mucous...cases and showed that diagnosis of primary HSV-1 gingivostomatitis in pregnant women...Department Pediatric C, 14 Kaplan St., IL-49202 Petah Tiqwa, Israel. Publisher...
- HSV-1 likely cause of new genital infections.(Infectious Diseases)(Herpes...
- Magazine article from: Internal Medicine News Mechcatie, Elizabeth November 15, 2005 700+ words
...vulvovaginal diseases. Young, sexually active women are more susceptible to HSV-1 because most do not have protective antibodies to HSV-1 due to the dramatic drop in childhood HSV-1 infections, said Dr. Hillier, director, reproductive infectious...
- HSV-2 underrecognized in HIV-positive patients: subclinical...
- Magazine article from: OB GYN News September 15, 2003 700+ words
...But it is now known that even asymptomatic HSV-2 infection can increase HIV transmissibility. "Both subclinical and clinical HSV-2 reactivation increase the frequency...a Seattle HIV clinic, 172 (70%) were HSV-2 seropositive; 42 had a history of symptomatic...
- HSV-2 Acquisition In Pregnancy High If Partner Infected: Partner testing is...
- Magazine article from: OB GYN News DeMott, Kathryn October 15, 2001 700+ words
...risk for contracting primary herpes simplex virus type 2 (HSV-2) infection, said Dr. Gardella of the University...to herpes but their partner was seropositive for either HSV-1, HSV-2, or both. Of the 125 women who were susceptible to...