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MnSOD expression after pancreatic cancer vaccination may be suppressive.
2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Animal and human experiments show promise for vaccination with manganese superoxide dismutase gene to suppress pancreatic cancer progression.
"Cells contain a large number of antioxidants to prevent or repair the damage caused by reactive oxygen species. One component of the antioxidant system, manganese superoxide dismutase (MnSOD), is localized in the mitochondria, and the levels of this protein have been previously shown to inversely correlate with pancreatic cancer cell growth.
"The aim of the present study was to determine whether MnSOD overexpression could suppress the in vitro and in vivo malignant phenotype of a human pancreatic cancer cell line," researchers in the United States report.
"Tumor cell behavior was determined in the pancreatic cancer cell line MIA PaCa-2 by examining cell growth, plating efficiency, and anchorage-independent growth in soft agar. MnSOD was overexpressed in the pancreatic cancer cell line MIA PaCa-2 by infection with an adenovirus-MnSOD construct. Cells were also injected s.c. in nude mice and tumor volume was calculated.
"Single and multiple direct injections of the adenoviral MnSOD construct (10[superscript]9 plaque-forming units) were delivered to the tumor. Increases in MnSOD immunoreactivity and activity were seen after transduction with the adenovirus-MnSOD construct. Increasing MnSOD levels correlated with ...
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Source: HighBeam Research, MnSOD expression after pancreatic cancer vaccination may be...