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Tumors that produce cyclooxygenase-2 are linked to poor prognosis.
2003 JUN 19 - (NewsRx.com & NewsRx.net) -- Expression of the protein cyclooxygenase-2 (COX-2) but not cyclooxygenase-1 (COX-1) in breast cancer tissue is a poor prognostic factor, linked to decreased survival, according to new research.
Expression of COX-2 was also associated with such poor prognostic factors as invasion into nearby lymph nodes and blood vessels, larger tumor size, and estrogen receptor negative status. In contrast, COX-1 expression had no statistically significant impact on patient prognosis, according to the study, reported in the June 15, 2003 issue of Cancer.
Given recent evidence that drugs that inhibit COX proteins called nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, reduce the risk of various type of cancer, "further studies will be required to determine whether COX-2 inhibitors may be useful for therapy or prevention of breast cancer," concluded the authors, Denkert et al. who conducted their study at the Charit University Hospital in Berlin.
The American Cancer Society estimates more than 211,000 women in the United States will be diagnosed with breast cancer in 2003. To help physicians and patients choose effective treatments, scientists have identified several factors that predict disease severity. These include the presence or absence of tumor cells in lymph nodes, tumor size, estrogen receptor negative status, and characteristics of the tumor cells themselves. Increasing evidence suggests that COX proteins may also be important factors in tumor severity.
COX proteins come in two primary forms, COX-1 and COX-2 and are more commonly implicated in inflammation. COX-1 is expressed in most tissues, while COX-2 is more selectively expressed. NSAIDs unselectively inhibit COX protein synthesis and are commonly used to control inflammation-related pain.
Recent studies using NSAIDs suggest a link between COX proteins and cancer risk. Regular use of NSAIDs has been associated with an 18% reduction in the risk of breast cancer. Furthermore, animal models have shown that ...
- COX-2 inhibitors may delay onset.(of breast cancer)
- Newspaper article from: Cancer Weekly November 12, 2002 700+ words
...use of a selective COX (cyclooxygenase...the incidence of breast cancer in HER-2/neu...in the onset of breast cancer in mice, there...potential role for using COX-2 inhibitors to prevent human breast cancer," according to...
- COX-2 inhibitors may delay onset.(breast cancer)
- Magazine article from: Women's Health Weekly November 14, 2002 700+ words
...use of a selective COX (cyclooxygenase...the incidence of breast cancer in HER-2/neu...in the onset of breast cancer in mice, there...potential role for using COX-2 inhibitors to prevent human breast cancer," according to...
- COX-2-derived prostaglandin E-2 is a potent breast cancer stimulant.
- Magazine article from: Women's Health Weekly March 11, 2004 700+ words
...NewsRx.net) -- COX-2-derived prostaglandin E-2 is a potent breast cancer stimulant. "Overexpression...human cyclooxygenase 2 (COX-2) in the mammary...These results define COX-2-derived PGE[subscript...cyclooxygenase 2-induced breast cancer progression. Proc Natl...
- Samoa's Rain Forest Savior - Looking for a cure for breast cancer, Paul Cox...
- Magazine article from: World and I Haapoja, Margaret A. September 1, 2002 700+ words
...Western influences. Here Cox began his research into...of finding a cure for breast cancer, the disease that took...youngest of three children, Cox was especially close...what I could to fight breast cancer," he says. "Then...plant that could help." Cox and his family lived
- GROUP REJECTS DOOM, GLOOM WOMEN WITH BREAST CANCER FIND NEW LIFE
- Newspaper article from: Post-Tribune (IN) October 16, 1988 700+ words
...LINDEMER, SUSAN COX, DOROTHY GILLESPIE - CHART About breast Cancer - To Contact SOURCE...Chesterton resident Susan Cox said, recalling how her own fight with breast cancer began five years...recent meeting. Breast cancer is hardly a topic...approach to life, Cox ...
- Risk assessment added to breast cancer campaign.
- Newspaper article from: Employee Health & Fitness February 1, 2000 700+ words
...health by launching a breast cancer risk assessment program...screenings, notes Sue Cox, RN, occupational...mammography, notes Cox, who says the company...This is not a fad, Cox adds. Everybody talks about [breast cancer screenings] everywhere...
- Fighting breast cancer: The latest diagnostic tools and treatments. (Health...
- Magazine article from: Sarasota Magazine Beiler, Pam January 1, 2002 700+ words
...patients. Dr. Charles E. Cox of the Comprehensive Breast Cancer Program at Moffitt says...to advanced stages of breast cancer, we've seen much...quality of life," Cox says. In the past, most breast cancer patients' lymph nodes...
- Breast cancer survivors scale mountains to raise money. (Originated from...
- Newspaper article from: Knight Ridder/Tribune News Service Anstett, Pat October 21, 1994 700+ words
...is pitch black when Ashley Cox, 22, awakens, grabs her...hates me right now,'' says Cox, a University of Montana junior...January to raise money for breast cancer research. Though many are...the team have in common is breast cancer. Some were diagnosed as recently...
