AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Long-term raloxifene reduces circulating levels of estradiol and estrone.
2003 JUN 19 - (NewsRx.com & NewsRx.net) -- Long-term raloxifene reduces circulating levels of estradiol and estrone.
According to a study from Italy, "The aim of the present study was to evaluate the effect of long-term (12 months) administration of raloxifene hydrochloride (60 mg/day) on the steroid production of the adrenal cortex and on the hypothalamic-pituitary-adrenal axis in postmenopausal women.
"We performed a basal evaluation, a corticotropin releasing factor (CRF) (100 microg I.V. bolus) test and a dexamethasone (DXM) (0.25 mg) suppression-adrenocorticotropic hormone (ACTH) (10 microg I.V. bolus) stimulation test in 11 postmenopausal women, before and after 3, 6 and 12 months of raloxifene treatment,." wrote A.R. Genazzani and colleagues, University of Pisa, Department of Reproductive Medicine & Child Development.
"Raloxifene administration significantly modified circulating levels of adrenal steroids, decreasing cortisol (-24%), dehydroepiandrosterone (DHEA) (-36%), and its sulfate (DHEAS) (-41%), and androsteriedione (-29%), and increasing circulating allopregnanolone (+39%) levels. Progesterone and 17OH-progesterone levels remained unmodified, while estradiol and estrone levels showed a significant decrease (-51% for estradiol and -61% for estrone)," the researchers stated.
"We also observed an increase in circulating A CTH (+58%) and beta-endorphin (+120%). No modifications in the hormonal responses to CRF were observed during the treatment. DXM significantly suppressed circulating steroids at any time with a lower suppression of cortisol from the third month and a higher suppression of DHEA at 12 months.
"ACTH administration was associated with a significantly blunted cortisol response from the sixth month and a significantly increased response of allopregnanolone from the third month," the researchers wrote.
"The present data exclude a ...
- Relation between stress and circulating levels of S100B protein reported.
- Newspaper article from: Biotech Week June 30, 2004 700+ words
...Scientists report the relation between stress and circulating levels of S100B protein in a recent issue of the journal Brain...study in Brain Research (Relationship between stress and circulating levels of S100B protein. Brain Res, 2004;1004(1-2...
- Cognitive Function in Postmenopausal Women Treated with Raloxifene.
- Magazine article from: OB/GYN Clinical Alert June 1, 2001 700+ words
...Berga, MD The main conclusion of this study is that short-term raloxifene exposure does not cause cognitive decline in relatively...osteoporosis. This study does not tell us whether long-term raloxifene use would increase, decrease, or not alter the risk of...
- Fact sheet on hormone replacement therapy and breast cancer.
- Magazine article from: The Network News Zones, Jane Sprague November 1, 2002 700+ words
...successfully created a SERM that reduces the risk of fracture without increasing the risk of breast cancer in the short term. * Raloxifene (Evista) is approved to prevent and treat osteoporosis. In one study, it reduced the number of breast cancer cases in...
- Extended raloxifene use cuts risk of breast Ca.(Gynecology)
- Magazine article from: OB GYN News Jancin, Bruce February 1, 2005 700+ words
...measurement might identify subgroups of osteoporotic women who are particularly likely or unlikely to benefit from long-term raloxifene in terms of breast cancer risk reduction proved largely unsuccessful. The magnitude of reduction in invasive breast cancer...
- Extended use of raloxifene cuts breast cancer risk: combined trials gather 8...
- Magazine article from: Family Practice News Jancin, Bruce February 15, 2005 700+ words
...measurement might identify subgroups of osteoporotic women who are particularly likely or unlikely to benefit from long-term raloxifene in terms of breast cancer risk reduction proved largely unsuccessful. The magnitude of reduction in invasive breast cancer...
- Is Circulating HER-2 a Prognostic Factor for Metastatic Breast Cancer Patients?
- Newspaper article from: Clinical Oncology Alert November 1, 2001 700+ words
...prognostic and predictive significance of circulating levels of extracellular domain of HER...cancers..sup.1 In addition, circulating levels of extracellular domain of HER...trastuzumab..sup.1 Thus, monitoring circulating levels of ECD/HER-2 in patients with...
- New atherosclerosis data have been reported by scientists at Central South...
- Newspaper article from: Blood Weekly January 8, 2009 700+ words
...investigate the probable association of circulating levels of PAI-1 and expression of PAI...score were analyzed in relation to circulating levels of PAI-1 and expression of PAI...were correlated significantly with circulating levels of PAI-1 (P < 0.01 and...
- Research reports on endotoxemia from Brigham and Women's Hospital, Medical...
- Newspaper article from: Blood Weekly October 8, 2009 700+ words
...systemic inflammatory response, circulating levels of HMGB1 are increased, but in a...wanted to determine whether tissue and circulating levels of HMGB1 are increased further in...HO-1(-/-) mice; however, circulating levels of HMGB1 were higher when compared...
Source: HighBeam Research, Long-term raloxifene reduces circulating levels of estradiol and...