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2003 JUN 19 - (NewsRx.com & NewsRx.net) -- Breast cancer metastasized to tamoxifen-associated endometrial polyps.
According to a study from Northern Ireland, "Two cases of lobular breast carcinoma metastatic to an endometrial polyp are described. Both patients had been treated with tamoxifen and presented with abnormal uterine bleeding.
"Histology of endometrial biopsy in both cases showed typical tamoxifen-associated endometrial polyps with focal subtle stromal infiltration by metastatic lobular breast carcinoma," wrote J.P. Houghton and colleagues, Royal Group Hospital Trust, Department of Pathology.
"This was confirmed by positive immunohistochemical staining with cytokeratin epithelial markers. Metastatic breast carcinoma may rarely involve tamoxifen-associated endometrial polyps," the researchers added.
The researchers concluded: "Because primary endometrial carcinomas may also arise within tamoxifen polyps, these ...