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Type 2 diabetes linked to prenatal diabetic environment?
2003 JUN 19 - (NewsRx.com & NewsRx.net) -- A preliminary study suggests that offspring of mothers with type 1 diabetes could be at an increased risk of type 2 diabetes in adult life - even in the absence of inherited type 1 or type 2 diabetic disease.
Type 2 diabetes generally occurs in adulthood and is caused by both genetic and environmental factors (such as obesity). Jean-Francois Gautier from Hopital Saint-Louis, Paris, and colleagues assessed whether prenatal exposure to a diabetic environment is associated with metabolic disorders in later adult life which can lead to type 2 diabetes.
The investigators assessed glucose tolerance and metabolic abnormalities that are predisposing to type 2 diabetes in offspring of mothers or fathers with type 1 diabetes. The confounding effect of genetic predisposition for type 2 diabetes was avoided by ensuring there was no family history of type 2 diabetes in either parent. Findings were published in the Lancet.
Insulin production in response to oral and intravenous glucose was measured in 15 nondiabetic adult offspring of mothers with type 1 diabetes (exposed participants) and 16 offspring of type 1 diabetic fathers (the control group). None of the participants had inherited type 1 diabetes.
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