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Transforming growth factor beta inhibits action of dendritic cell vaccines.
2003 JUN 18 - (NewsRx.com & NewsRx.net) -- Transforming growth factor beta inhibited the antigen-presenting functions and antitumor activity of dendritic cell vaccines.
"Dendritic cell (DC)-based vaccines have exhibited minimal effectiveness in treating established tumors, likely because of factors present in the tumor micro-environment. One such factor is transforming growth factor beta (TGF-beta), a cytokine that is produced by numerous tumor types and has been demonstrated to impair DC functions in vitro. We have evaluated the effect of TGF-beta on the immunostimulatory activities of DCs," researchers in the United States report.
"We demonstrate that TGF-beta exposure inhibits the ability of DCs to present antigen, stimulate tumor-sensitized T lymphocytes, and migrate to draining lymph nodes," said James J. Kobie and collaborators at the University of Arizona, Lafayette College, and Vanderbilt University. "Neutralization of TGF-beta using the TGF-beta-neutralizing monoclonal antibody 2G7 enhanced the ability of DC vaccines to inhibit the growth of established 4T1 murine mammary tumors. Treatment of 4T1 tumors transduced with the antisense TGF-beta ...
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- Immature dendritic cell vaccine causes immune response against melanoma.
- Newspaper article from: Vaccine Weekly April 9, 2003 700+ words
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