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Antigen silencing in melanomas induced by oncostatin M.
2003 JUN 18 - (NewsRx.com & NewsRx.net) -- Antigen silencing in melanoma tumors is induced by oncostatin M.
"We previously reported that antigen expression in melanoma cell lines is down-regulated by proteins secreted by antigen-negative melanoma cells. Here we report the purification and characterization of one of these down-regulatory factors, the cytokine, oncostatin M (OSM), which transmits its signal via the gp130 cell surface receptor, resulting in the selective down-modulation of the melanocyte lineage antigens: MelanA/MART-1, gp100, tyrosinase, tyrosinase-related proteins 1 and 2, and the M isoform of microphthalmia transcription factor.
"Furthermore, we have found that some melanoma cell lines produce as yet uncharacterized factors distinct from OSM which also down-modulate antigen expression via signaling pathways different from that employed by OSM," scientists in the United States report.
"These data indicate that there may be several regulatory pathways and molecules involved in the antigen-silencing process ...
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Source: HighBeam Research, Antigen silencing in melanomas induced by oncostatin M.