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Maternal vaccination against nicotine reduces nicotine to the fetal brain.
2003 JUN 18 - (NewsRx.com & NewsRx.net) -- Maternal vaccination against nicotine reduced nicotine distribution to the fetal brain in rats.
"Cigarette smoking during pregnancy is associated with a variety of adverse fetal outcomes. Nicotine is a likely contributor to these adverse effects, with fetal brain as one target organ. Vaccination of adult male rats against nicotine has been shown to reduce nicotine distribution to the brain," scientists writing in the Journal of Pharmacology and Experimental Therapeutics report.
"The current study examined whether vaccination of female rats before pregnancy would reduce the distribution to fetal brain of a single nicotine dose administered during gestation," said Daniel E. Keyler and collaborators at the Hennepin County Medical Center and University of Minnesota. "Female rats immunized with a nicotine conjugate vaccine received a single dose of nicotine 0.03 mg/kg i.v. on gestational day 16 to 22. Five minutes later, vaccinated rats had substantially higher bound and lower unbound serum nicotine concentration and lower brain nicotine concentration than controls.
"Fetal brain nicotine concentration was reduced by 43% in vaccinated rats, comparable to the reduction in the maternal brain nicotine concentration. The whole-fetus nicotine concentration was not altered by vaccination."
"A similar experiment was performed in which pregnant rats were passively immunized with rabbit nicotine-specific IgG 7 or 21 mg/kg just before nicotine dosing," ...
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