AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Influenza vaccine with adjuvant more effective in elderly high-risk adults.
2003 JUN 18 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Results from a meta-analysis indicate that the influenza vaccine containing MF59 adjuvant is more immunogenic in elderly patients with chronic disease than is the conventional influenza vaccine.
"The elderly are at a higher risk of morbidity and mortality associated with influenza infection than younger adults, but get less protection from conventional vaccination," said Angelika Banzhoff and collaborators at Chiron Vaccines in Siena, Italy and Marburg, Germany. "We conducted a meta-analysis of all available data from clinical trials in the elderly on a recently introduced MF59-adjuvanted influenza vaccine to determine its immunogenicity and safety in subjects with underlying chronic disease who are at highest risk of influenza infection."
The investigators analyzed 13 trials involving 3,600 subjects who received the new influenza vaccine or the conventional vaccine without the adjuvant.
At 28 days, geometric mean hemagglutination inhibition titer (GMT) was significantly higher in elderly subjects with chronic disease who received the adjuvanted vaccine with the A/H3N2 antigen compared to those who received vaccine without antigen (p=0.004). The MF59/conventional GMT ratio was 1.37 for chronically ill older adults vaccinated with the B antigen (p=0.065) and 1.17 for those receiving the A/H1N1 antigen (p=0.41).
No serious adverse effects from the MF59-adjuvanted influenza vaccine were reported, although minor effects ...
- Subunit-adjuvanted influenza vaccine more immunogenic than split vaccine.
- Newspaper article from: Vaccine Weekly April 9, 2003 700+ words
...net) -- A subunit-adjuvanted influenza vaccine was more immunogenic in...inactivated, split virion influenza vaccine (Vaxigrip, Aventis Pasteur...split and a subunit-adjuvanted influenza vaccine in elderly subjects...
- Influenza vaccine with adjuvant more effective in elderly high-risk adults.
- Newspaper article from: Biotech Week June 18, 2003 700+ words
...recently introduced MF59-adjuvanted influenza vaccine to determine its immunogenicity...effects from the MF59-adjuvanted influenza vaccine were reported, although...vaccine. "The MF59-adjuvanted influenza vaccine is more immunogenic...
- Juvaris BioTherapeutics Initiates Phase 2 Study of Influenza Vaccine Adjuvant...
- Press release article from: Business Wire November 2, 2009 700+ words
...to trivalent inactivated influenza vaccine administered with and without...cellular immunity) to the influenza vaccine. The study is also intended...States. "Developing an adjuvanted influenza vaccine to confer superior immunity...
- Juvaris BioTherapeutics Begins Phase 2 Study of Influenza Vaccine Adjuvant in...
- Magazine article from: Health & Beauty Close-Up November 4, 2009 700+ words
...to trivalent inactivated influenza vaccine administered with and without...cellular immunity) to the influenza vaccine. The study is also intended...States. "Developing an adjuvanted influenza vaccine to confer superior immunity...
- European Mutual Recognition Approval of Chiron's Influenza Vaccine Fluad(R)...
- Press release article from: PR Newswire May 24, 2000 700+ words
...Procedure to market its adjuvanted influenza vaccine Fluad(R) in 12 Western...largest segment of the influenza vaccine market. The vaccine contains...expands Chiron's European influenza vaccine portfolio, which includes...
- Nanoemulsion-Based Intranasal Influenza Vaccine Adjuvant Triggers Robust...
- Press release article from: PR Newswire October 27, 2008 700+ words
...administration of a novel, nasally delivered influenza vaccine elicited immune responses in ferrets that were...5, 15 and 45 micrograms of nanoemulsion- adjuvanted influenza vaccine (n=12 ferrets/dose). All three doses produced...
- Chiron Announces Promising Data from Clinical Study of Adjuvanted Avian...
- Press release article from: Business Wire October 28, 2005 700+ words
...ranged from 3.75 to 30 micrograms. "This study builds on the clinical data Chiron has already established with adjuvanted influenza vaccines," said Rino Rappuoli, Ph.D., chief scientific officer of Chiron and head of research for Chiron...
- Publication No. WO/2009/109550 Published on Sept. 11, French Inventors Develop...
- News wire article from: US Fed News Service, Including US State News September 16, 2009 700+ words
...adjuvanted vaccine composition in dry form and in particular a process for stabilizing an influenza vaccine composition, particularly an adjuvanted influenza vaccine composition in dry form." The invention carries International Patent Publication...
