AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Mycobacterial Apa protein immunogenic.
2003 JUN 11 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in India have identified a mycobacterial protein that could be used as the basis for a tuberculosis vaccine.
"The search to identify Mycobacterium tuberculosis antigens capable of conferring protective immunity against tuberculosis has received a boost owing to the resurgence of tuberculosis over the past two decades," explained Priti Kumar and colleagues at the Indian Institute of Science and the National Tuberculosis Institute in Bangalore. "It has long been recognized that lymphoid cells are required for protection against M. tuberculosis."
The pathogen's Apa protein had a protective effect in animals as part of a prime-boost DNA vaccine regimen, Kumar and coauthors reported.
Peripheral blood cells from purified protein derivative (PPD)-positive individuals responded strongly to Apa exposure, with both lymphoproliferative activity and gamma interferon (IFN-gamma) secretion, the researchers said. The antigen provoked Th1 cytokine production from both cytotoxic and helper T cells.
A DNA vaccine based on Apa provided only modest protection in a guinea pig model of M. tuberculosis infection, test results showed. However, DNA vaccine priming followed by boosting ...
- Powderject DNA vaccine achieves protective immunity.(Brief Article)
- Newspaper article from: BIOTECH Patent News April 1, 2001 700+ words
...achievement of protective immunity by a DNA vaccine in volunteers who do not respond to...preliminary data from the hepatitis B DNA vaccine clinical study will be presented at...study is part of PowderJect's major DNA vaccine collaboration with GlaxoSmithKline...
- PowderJect DNA Vaccine First to Achieve Protective Immunity in Non-Responders...
- Press release article from: PR Newswire April 24, 2001 700+ words
...achievement of protective immunity by a DNA vaccine in volunteers who do not respond to...preliminary data from the hepatitis B DNA vaccine clinical study will be presented today...study is part of PowderJect's major DNA vaccine collaboration with GlaxoSmithKline...
- Vical Introduces RapidResponse(TM) DNA Vaccine Cell-Free Platform Designed to...
- Press release article from: PR Newswire June 4, 2007 700+ words
...today announced the RapidResponse(TM) DNA vaccine platform designed to produce large quantities...of Vical. "The RapidResponse(TM) DNA vaccine platform has the potential to develop...genetic sequence." RapidResponse(TM) DNA vaccine manufacturing involves a cell-free...
- DNA vaccine protected chimps from AIDS virus, scientists say.(Originated from...
- Newspaper article from: Knight Ridder/Tribune News Service Collins, Huntly Shaw, Donna April 29, 1997 700+ words
...infection with the AIDS virus. The DNA vaccine is made with the genetic material of...are the first to demonstrate that a DNA vaccine can confer protection against HIV in...achieve protection in chimps with a DNA vaccine,'' said William Paul, an immunologist...
- Vical Advances RapidResponse(TM) DNA Vaccine Platform Under $6 Million Grant...
- Press release article from: PR Newswire June 25, 2008 700+ words
...advancing with the development of a DNA vaccine manufacturing process with the potential...Platform The RapidResponse(TM) DNA vaccine manufacturing platform is intended to...dedicated facilities. RapidResponse(TM) DNA vaccine manufacturing involves a cell-free...
- Vical's DNA Vaccine Provides Complete Protection Against Avian Influenza and...
- Press release article from: PR Newswire May 2, 2006 700+ words
...three-component influenza (flu) DNA vaccine candidate provided 100 protection in...the company's program to develop a DNA vaccine that protects humans against emerging...toward human testing of the pandemic flu DNA vaccine candidate. "We are encouraged by the...
- Vical Receives $6 Million Grant From NIH to Advance RapidResponse(TM) DNA...
- Press release article from: PR Newswire June 12, 2007 700+ words
...NIH), for further development of a DNA vaccine manufacturing process with the potential...Platform The RapidResponse(TM) DNA vaccine manufacturing platform is intended to...dedicated facilities. RapidResponse(TM) DNA vaccine manufacturing involves a cell-free...
- DNA vaccine against Streptococcus mutans characterized.
- Newspaper article from: Health & Medicine Week May 3, 2004 700+ words
...characterized a fusion anti-caries DNA vaccine against PAc and glucosyltransferase...against caries, we constructed a fusion DNA vaccine, pGLUA-P, by cloning the GLU region of GTF into a DNA vaccine, pCIA-P, which encodes two highly...
Source: HighBeam Research, Mycobacterial Apa protein immunogenic.