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CD4+CD25+ T cells are key regulators of immune responses.

Vaccine Weekly

| June 11, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 JUN 11 - (NewsRx.com & NewsRx.net) -- CD4+CD25+ T cells are key regulators of immune responses, and understanding their function may lead to more effective vaccines for autoimmune and inflammatory diseases.

According to published research from France, "Discredited a few years ago, active suppression is now commonly considered as a key mechanism avoiding auto-reactivity and development of potentially harmful immune responses, and in some circumstances, as an obstacle to successful vaccination."

"A large quantity of literature identifies naturally occurring CD4+CD25+ T cells as key suppressor cells involved in the control of many pathophysiological diseases," reported Bertrand Dubois and collaborators at INSERM U404. "Manipulation of these cells and control of their function offers new perspectives for the treatment of auto-immune and inflammatory diseases and enhancement of vaccine efficacy. Such clinical interventions require ...

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