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Immune transfer through stem cell transplantation effective.
2003 JUN 11 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Germany have identified a novel method of inducing immunity to hepatitis B virus (HBV) infection.
"Previous data indicate that a transfer of specific humoral and cellular immunity by way of allogeneic hematopoietic cell transplantation (HCT) should, in principle, be possible," explained Monika Lindemann and colleagues at the University of Essen and Georg-August University in Goettingen.
Recipients of stem cell grafts from vaccinated donors demonstrated HBV-specific immune responses after transplantation, Lindemann and coauthors confirmed.
The researchers examined cellular and humoral immune activity in 27 patients who underwent stem cell transplantation to treat chronic myeloid leukemia. None of these patients had HBV-specific immunity prior to transplantation, they noted.
Anti-HBV antibodies were seen in 86% of transplanted patients after two weeks, with HBV-specific cellular activity found in 67% of these patients, study data indicated. Although transient, these humoral and cellular responses reappeared in more than 80% of stem cell recipients without further ...
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Source: HighBeam Research, Immune transfer through stem cell transplantation effective.