Host absence of CCR5 potentiates dendritic cell vaccination.

2003 JUN 11 - (NewsRx.com & NewsRx.net) -- The absence of CCR5 in the host potentiated dendritic cell vaccination.

According to a study from the United States, "Previous work has shown that dendritic cells (DCs) express specific chemokine receptors that allow for coordinated movement in vivo. To test the in vivo relevance of this, we used a murine melanoma system and knockout mice to investigate the function of the chemokine receptor CCR5 and its ligands, CCR ligand (CCL)3 and CCL5. We found that the lack of CCR5 in the host mouse resulted in delayed tumor growth, but this effect was overcome at a higher tumor load."

"With the administration of tumor charged DCs, CCR5-/- mice that had previously been injected with tumor were completely protected from tumor, reported Judith Ng-Cashin and colleagues at the University of North Carolina. "This effect was dependent on the dose of tumor cells and the expression of CCR5 on the DC and its absence in the host. In contrast, the loss of the CCR5 ligand, CCL3, led to an early delay in tumor ...