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Removing CD4+ T cells overcomes suppression of anti-HER2 immune responses.
2003 JUN 11 - (NewsRx.com & NewsRx.net) -- Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts.
"In this study, we analyzed specific anti-tumor immune responses in tumor-bearing hosts by measuring HER2-specific CD8+ T cell responses," scientists in Japan report.
"No measurable HER2-derived peptide (HER2p63)-specific CD8+ T cells were present in the spleens of mice in the early to late phase of tumor-bearing," stated M. Ishihara and colleagues at Mie University. "Vaccination with HER2 protein and cholesteryl group-bearing pullulan (CHP-HER2 complex) induced HER2-specific CD8+ T cells, but their numbers continuously declined as tumors continued growing. Removal of CD4+ T cells by anti-CD4 monoclonal antibody in the early tumor-bearing stage resulted in tumor regression. The combination of CHP-HER2 complex vaccination and depletion of CD4+ T cells enhanced and restored HER2-specific CD8+ T cells in the late stage of tumor-bearing, and ...
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Source: HighBeam Research, Removing CD4+ T cells overcomes suppression of anti-HER2 immune...