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Interleukin 12 is promising adjuvant for cancer vaccination.
2003 JUN 11 - (NewsRx.com & NewsRx.net) -- Interleukin 12 offers promise as an adjuvant for cancer vaccines.
"The clinical development of interleukin 12 (IL-12) as a single agent for systemic cancer therapy has been hindered by its significant toxicity and disappointing anti-tumor effects. The lack of efficacy was accompanied by, and probably related to, the declining biological effects of IL-12 in the course of repeated administrations at doses approaching the maximum tolerated dose (MTD). Nevertheless, IL-12 remains a very promising immunotherapeutic agent because recent cancer vaccination studies in animal models and humans have demonstrated its powerful adjuvant properties," scientists in Netherlands report.
"Therefore, IL-12 may re-enter the arena of cancer therapy," said Johanna E. A. Portielje and colleagues at the Erasmus Medical Center in Rotterdam. "Here, we review the immune modulating characteristics of IL-12 considered responsible for the adjuvant effects, as well as the results of animal and human cancer vaccination studies with IL-12 applied as an adjuvant. In ...
- TARGETED GENE DELIVERY SIGNALS CANCER VACCINATION IN VIVO: Intravenous...
- Press release article from: PR Newswire May 27, 2008 700+ words
...followed by Reximmune-C -- for cancer vaccination will be presented at the ASCO meetings...effort to achieve a personalized cancer vaccination in vivo. Seven patients with chemo...the potential for a personalized cancer vaccination using this sequential gene transfer...
- Cervical cancer vaccination must proceed, says expert
- Newspaper article from: The Irish Times KITTY HOLLAND September 7, 2009 700+ words
THE NATIONAL cervical cancer vaccination programme had been due to begin this week and the Minister for Health, Mary Harney, must now fulfil her commitment to reinstitute...
- Merck backs off campaign to make cervical cancer vaccination school entry...
- Magazine article from: Guttmacher Policy Review Sonfield, Adam January 1, 2007 700+ words
...suspend its aggressive campaign to persuade state governments to make Gardasil--the company's anti-cervical cancer vaccination--a requirement for preteen girls to attend school. Merck's about-face comes as states across the country...
- Merck and QIAGEN Collaborate to Accelerate Access to Cervical Cancer...
- Newspaper article from: Cancer Vaccine Week October 5, 2009 700+ words
...Merck and QIAGEN strongly believe that working together to develop country-wide programs that include cervical cancer vaccination and screening would bring unique benefits to global public health. GARDASIL has received WHO prequalification...
- New cervical cancer vaccination begins in Vanuatu.
- News wire article from: PAC - Pacific Islands Broadcasting Association March 23, 2009 700+ words
23 MARCH 2009 PORT VILA (Pacnews) A vaccination programme which aims to prevent women from the deadly cervical virus diseases and involved the vaccination of 10 to 12 year old girls has kicked off this morning at Freshwota School in the capital, Port Vila. The programme was introduced following
- U-turn on cervical cancer vaccination; HEALTH: Policy change from NHS...
- Newspaper article from: Birmingham Mail (England) August 8, 2009 700+ words
Byline: Alison Dayani HEALTH bosses in part of the city have made a U-turn on vaccinating teenagers against cervical cancer after figures showed girls were missing out on the life-saving jab in their area. NHS Birmingham East and North only offered HPV (Human Papillomavirus Vaccine) in GP
- A shot in the arm for cancer. (vaccination for hard-to-treat tumors)
- Magazine article from: U.S. News & World Report McAuliffe, Kathleen April 4, 1988 700+ words
A shot in the arm for cancer therapy Almost two centuries after vaccination first triumphed over infectious organisms that invade the body from outside, the same preventive strategy is being harnessed against the invader from within--cancer. Paradoxically, it is the cancerous tissue itself that is
- Girl suffers brain damage after jab; HEALTH: 17-year-old's problems started...
- Newspaper article from: Birmingham Mail (England) October 5, 2009 700+ words
Byline: Chris Henwood A BLACK Country teenager suffered brain damage after falling ill within days of being given a controversial new cervical cancer vaccine on offer to all schoolgirls under a government programme. Bilston 17-year-old Stacey Jones suffered her first epileptic seizure days after
Source: HighBeam Research, Interleukin 12 is promising adjuvant for cancer vaccination.