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MMR vaccine and secretin or its receptor may share an antigenic epitope.

Vaccine Weekly

| June 11, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 JUN 11 - (NewsRx.com & NewsRx.net) -- The MMR vaccine and secretin or its receptor may share an antigenic epitope.

"In a subgroup of children with autism-spectrum like conditions, symptoms seem to appear as a 'regression' (in normal development). It has been postulated that the onset of such autistic symptoms may involve an autoimmune response against the central nervous system and that the antigenic determinant could possibly be gastrointestinal in origin. It has been suggested that the presence of the measles virus and 'autistic enterocolitis' demonstrates the possibility that the MMR triple vaccine may be mediating the inflammation with possible production of antibodies against the virus containing vaccine," scientists in Canada report.

"Such an antibody may share antigenic determinant to molecules found in the gut," suggested Bijal K. Mehta at Memorial University of Newfoundland and Kerim M. Munir at St. John's in Newfoundland, Canada. "We propose that this may be secretin or its receptor, found in the gut as well as in the central nervous system. The antibody response to the gut may also conceivably occur in the brain at a critical time in development: The modulation of development by secretin may be a static event ...

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