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Single dose of DNA vaccine protects mice against tuberculosis.
2003 JUN 11 - (NewsRx.com & NewsRx.net) -- A single dose of a vaccine based on DNA encoding mycobacterial hsp65 protein plus TDM-loaded PLGA microspheres protected mice against a virulent strain of Mycobacterium tuberculosis.
"The high incidence of tuberculosis around the world and the inability of BCG to protect certain populations clearly indicate that an improved vaccine against tuberculosis is needed. A single antigen, the mycobacterial heat shock protein hsp65, is sufficient to protect BALB/c mice against challenge infection when administered as DNA vaccine in a three-dose-based schedule," scientists in Brazil report.
"In order to simplify the vaccination schedule, we co-encapsulated hsp65-DNA and trehalose dimicolate (TDM) into biodegradable poly(DL-lactide-co-glycolide) (PLGA) microspheres," stated K. M. Lima and colleagues at the University of Sao Paulo. "BALB/c mice immunized with a single dose of DNA-hsp65/TDM-1oaded microspheres produced high levels of IgG2a subtype antibody and high amounts of IFN-gamma in the supernatant of spleen cell cultures. DNA-hsp65/TDM-loaded microspheres were also able to induce high IFN-gamma production in bulk lung cells from challenged mice and confer protection as effective as that attained after ...
- DNA vaccine with pneumococcal surface protein A elicits immune responses.
- Newspaper article from: Biotech Week August 6, 2003 700+ words
...antibody response by a DNA vaccine expressing a C...Instituto Butantan in Sao Paulo. "In this work we show that the DNA vaccine expressing the C...1500, 05503-900 Sao Paulo, SP, Brazil...Pneumococcal Vaccine, DNA Vaccine, Vaccine Development...
- Data on cancer gene therapy vaccines described by researchers at University of...
- Newspaper article from: Cancer Gene Therapy Week June 29, 2009 700+ words
...patients.' "DNA-hsp65, a DNA vaccine encoding the 65-kDa heat...carcinoma," scientists in Sao Paulo, Brazil report (see also...colleagues, University of Sao Paulo, Heart Institute. The researchers...Victora, University of Sao Paulo, Laboratory of Immunology...
- Single dose of DNA vaccine protects mice against tuberculosis.
- Newspaper article from: Immunotherapy Weekly June 11, 2003 700+ words
...administered as DNA vaccine in a three-dose...the University of Sao Paulo. "BALB/c mice...University of Sao Paulo, Av. Bandeirantes...Ribeirao Preto, Sao Paulo 14049-900, Brazil...Tuberculosis Vaccine, DNA Vaccine, Microencapsulation...
- DNA vaccine activates CD8+ cells and reduces lung injury in TB.
- Newspaper article from: Biotech Week October 20, 2004 700+ words
...study from Brazil, "A DNA vaccine based on the heat...at the University of Sao Paulo and Sao Paulo State University...Medicine, University of Sao Paulo, Avenue Bandeirantes...Tuberculosis Therapy, DNA Vaccine, Bacteriology, Mycobacteria...
- Efficacy of tuberculosis DNA vaccine varies with method of DNA introduction.
- Newspaper article from: Medical Letter on the CDC & FDA April 25, 2004 700+ words
...of DNA introduction in vivo. "A DNA vaccine codifying the mycobacterial hsp65...and colleagues at the University of Sao Paulo. "Immunization by gene gun induced...Delivery, Vaccine Development, and DNA Vaccine. This article was prepared by Medical...
- Sao Paulo.(BEST OF BRAZIL)(Restaurant review)
- Rio & the Best of Brazil Alive January 1, 2007 700+ words
It may seem odd to place Sao Paulo, the largest city in Brazil, at...this. Virtually all travelers to Sao Paulo are here on business. The city has...have been replaced by sky scrapers. Sao Paulo does not have the lure of Rio's...
- All things come to towns that wait. (growth and power in Sao Paulo, Brazil)
- Magazine article from: The Economist (US) September 3, 1988 700+ words
FOR generations, the city of Sao Paulo suffered from not being Rio de Janeiro...capital. The paulistanos, the people of Sao Paulo, loved weekends in Rio; Rio's cariocas kept well clear of Sao Paulo. Rio had football, samba, pretty women...
- Sao Paulo: Urbanization Run Amok.(economic problems of Sao Paulo, Brazil)
- Magazine article from: World and I Henkin, Stephen August 1, 1999 700+ words
...the myriad difficulties now plaguing Sao Paulo, Brazil. With 21.4 million residents...resembles the satellite communities of Sao Paulo in the 1960s, which came together in...CONTRASTS A city of stark contrasts, Sao Paulo has a business-development side that...
