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Therapeutic vaccine effective against EBV-associated cancers.
2003 JUN 11 - (NewsRx.com & NewsRx.net) -- A therapeutic LMP1 polyepitope vaccine has been developed for Epstein-Barr virus (EBV)-associated Hodgkin's disease and nasopharyngeal carcinoma.
According to a study from Australia, "Development of an epitope-based vaccination strategy designed to enhance Epstein-Barr virus (EBV)-specific CD8+ cytotoxic T lymphocytes (CTLs) is increasingly being considered as a preferred approach for the treatment of EBV-associated relapsed Hodgkin disease (HD) and nasopharyngeal carcinoma (NPC). EBV-encoded latent membrane proteins, LMP1 and LMP2, are the only target antigens available for therapeutic augmentation of CTL responses in patients with HD and NPC. Here, we describe preclinical studies using a recombinant poxvirus vaccine that encodes a polyepitope protein comprising 6 HLA A2-restricted epitopes derived from LMP1."
"Human cells infected with this recombinant polyepitope construct were efficiently recognized by LM1-specific CTL lines from HLAA2 healthy individuals," reported Jaikumar Duraiswamy and collaborators at the University of Queensland and Australian National University. "Furthermore, immunization of HLrA A2/K-b mice with this polyepitope vaccine consistently generated strong LMP1-specific CTL responses to five of the six epitopes, ...
- ISSI Signs EBV Elektronik as a Franchise Distributor in Europe for Its Complete...
- Press release article from: PR Newswire April 2, 2002 700+ words
...solutions, today announced that it has signed EBV Elektronik, one of Europe's largest independent...as its franchised partner in Europe. EBV Elektronik and its group will distribute...Fischer, ISSI's president and COO. "EBV adds value to our broad line of memory products...
- Early anti-EBV cytotoxic immune response impaired in HIV patients.
- Newspaper article from: Biotech Week May 5, 2004 700+ words
...early cytotoxic response to Epstein-Barr virus (EBV) is impaired in HIV patients. According to recent...mmunodeficiency related to HIV may increase the incidence of EBV-associated lymphomas, by altering EBV-specific immune control and consequently favoring...
- EBV viral load increases and reaches setpoint after HIV seroconversion.
- Newspaper article from: Virus Weekly August 3, 2004 700+ words
...situation in the post-transplant setting, in HIV-infected individuals an elevated EBV load is not predictive of EBV-related malignancies. "To study whether a high EBV load is already a normal situation early in HIV infection and is not related to...
- Modification of C[epsilon] mRNA expression by EBV-encoded latent membrane...
- Magazine article from: Mediators of Inflammation Hanashiro, Kazuhiko Ohta, Shigeto Sunagawa, Masanori Nakamura, Mariko Suzuki, Mikio Kosugi, Tadayoshi January 1, 2006 700+ words
...LMP) 1 encoded by Epstein-Barr virus (EBV) on C[epsilon] mRNA expression, mRNA...allergen. INTRODUCTION Epstein-Barr virus (EBV) is a member of the human herpesvirus family...90% of the world's adult population. EBV infects the oropharynx tissues such as tonsils...
- DiaSorin Receives FDA Approval for Epstein Barr Virus Multiplex(TM) EBV-M for...
- Press release article from: PR Newswire June 30, 1999 700+ words
...testing of multiple Epstein Barr Virus (EBV) assays through its Copalis(R) Multiplex technology. Numerous studies show EBV is the causative agent in 90% of infectious...single sample. Copalis(R) Multiplex EBV, with the Copalis(R) EBV-M assay...
- CE test on LABORATORY-BASED INVESTIGATIONS OF IM AND EBV.(CONTINUING...
- Magazine article from: Medical Laboratory Observer January 1, 2007 700+ words
...LABORATORY-BASED INVESTIGATIONS OF IM AND EBV. CEUs or contact hours are granted by the...DeKalb, IL. 1. The Epstein-Barr virus (EBV) contains all of the following features...structural capsid. 2. Infants infected with EBV are more likely to experience symptomatic...
- Fairchild Semiconductor and EBV Elektronik Simplify the Tracking and Support of...
- Press release article from: Business Wire December 7, 2005 700+ words
...one of Europe's largest distributors, EBV Elektronik, an Avnet (NYSE: AVT) Company...Data Exchange process enables Fairchild and EBV Elektronik to communicate and track new...saving enables us to more efficiently support EBV Elektronik's design requirements and respond...
- Celoxica and EBV Elektronik Combine ESL Design With Semiconductor Supply Chain...
- Press release article from: Business Wire November 27, 2006 700+ words
...CXA), today announced cooperation with EBV Elektronik, an Avnet (NYSE:AVT) company...technology such as Nios II or DSP processors. EBV already provides end-to-end supply chain...knowledge and expertise in conjunction with EBV technical staff. Initially focusing on...
Source: HighBeam Research, Therapeutic vaccine effective against EBV-associated cancers.