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HRT is safe, effective for prevention, treatment in older women.
2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Elderly women with osteoporosis can significantly and safely improve their bone mass with a combination therapy of hormone replacement and the bisphosphonate alendronate (Fosamax).
"Our study found that a combination therapy of hormone replacement and alendronate was well tolerated by elderly women with low bone mass. After 3 years of treatment, these women showed significantly greater increases in bone mass than we saw in similar women taking only one of the therapies," said lead author Susan Greenspan, MD, professor of medicine at the University of Pittsburgh School of Medicine and director of the Osteoporosis Prevention and Treatment Center at the University of Pittsburgh Medical Center. "Combination therapy is a safe, viable option for postmenopausal women who have been unable to improve their bone density with an individual therapy, or in women with osteoporosis severe enough to require a greater increase in bone density."
Earlier research has suggested similar results with younger women, but up to now little data were available on the effectiveness and safety of combination therapy in older, post-menopausal women.
The study was conducted with 373 women aged 65 to 90 years. At baseline, participants as a group had bone mass thin enough to be classified as osteopenia, a precursor of osteoporosis. Thirty-four percent of the women had osteoporosis.
Participants were evenly randomized to receive hormone replacement therapy (HRT) (conjugated estrogen with or without medroxyprogesterone) plus ...
- HRT Linked to Higher Risk Of Adult-Onset Asthma.
- Magazine article from: Family Practice News BOSCHERT, SHERRY December 15, 2000 700+ words
...replacement therapy (HRT). Current use of estrogen...estrogen monotherapy or combination therapy in the past saw their...those who had never used HRT. All data were adjusted...asthma and COPD, and combination therapy raised risk by 30...increase in risk. "HRT may worsen ...
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- Magazine article from: OB GYN News BOSCHERT, SHERRY December 15, 2000 700+ words
...replacement therapy (HRT). Current use of estrogen...estrogen monotherapy or combination therapy in the past saw their...those who had never used HRT. All data were adjusted...asthma and COPD, and combination therapy raised risk by 30...increase in risk. "HRT may worsen ...
- Addition of Alendronate to Ongoing HRT in the Treatment of Osteoporosis: A...
- Magazine article from: Internal Medicine Alert February 15, 2000 700+ words
...density (BMD) than the use of HRT alone. A total of 428 postmenopausal...young women and who had used HRT for at least one year were randomized...lumbar spine was 3.6% for combination therapy vs. 1.0% for HRT alone (P[less than]0...
- POTPOURRI: Dilemma of HRT
- Newspaper article from: Filipino Reporter Prudencio R. Europa September 28, 1995 700+ words
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- HRT Improves Pulmonary Function in Elderly.
- Magazine article from: OB GYN News WALD, ADRIENNE April 1, 2001 700+ words
...replacement therapy, especially combination therapy, was associated with improved...postmenopausal women. Current HRT users were about 25% less...women who either had never used HRT or were former users, after...10% higher in current HRT users, and mean forced vital...
- Combination HRT linked to dementia in older women: findings reinforce need to...
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...women taking HRT around the menopausal...outcomes in women on combination therapy he added. In...women on the combination therapy (JAMA 289...drafting a set of HRT guidelines that...showing that combination therapy increased the...
- Pulmonary Function Helped By HRT Use.(Brief Article)
- Magazine article from: Family Practice News WALD, ADRIENNE April 1, 2001 700+ words
...replacement therapy, especially combination therapy, was associated with improved...postmenopausal women. Current HRT users were about 25% less...than women who had never used HRT or were former users, after...10% higher in current HRT users, and mean forced vital...
- ETHICAL HOLDING PLC ANNOUNCES UK SUBMISSION FOR HRT COMBINATION PATCH
- Press release article from: PR Newswire June 12, 1996 700+ words
...companies in the rapidly expanding HRT market. Ethical looks forward...for Schering, Ethical's HRT product portfolio consists...single hormone replacement and combination therapy transdermal patches. Ethical...and as part of a combination HRT package containing Solvay...
Source: HighBeam Research, HRT is safe, effective for prevention, treatment in older women.