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Maspin mRNA has prognostic value in postmenopausal breast carcinomas.
2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Maspin mRNA has prognostic value in postmenopausal breast carcinomas.
"Maspin, a member of the serpin family, has a role in cell migration, angiogenesis and apoptosis. Little is known of the clinical significance of maspin gene expression in human cancers. We developed a real-time quantitative RT-PCR assay to quantify the full range of maspin mRNA copy numbers in a series of 10 estrogen receptor (ER)alpha-positive and 10 ERalpha-negative breast tumors," investigators in France reported.
"We observed a statistical link between low maspin mRNA levels and positive estrogen status (p=0.0012). In consequence, to better assess the prognostic value of maspin gene expression in breast cancer, we then quantified maspin mRNA content in an additional independent well-defined cohort of 105 ERalpha-positive postmenopausal breast cancer patients treated with primary surgery followed by adjuvant tamoxifen alone," said I. Bieche and colleagues, Rene Huguenin Center, INSERM.
"Maspin expression varied widely in tumor tissues (by nearly four orders of magnitude), being underexpressed in 33 out of 105 tumors (31.4%) and overexpressed in 24 out of 105 tumors (22.9%) relative to normal breast tissues."
"Immunohistochemical studies demonstrated that maspin protein was strictly expressed in myoepithelial cells of normal breast tissue and in tumor epithelial ...
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Source: HighBeam Research, Maspin mRNA has prognostic value in postmenopausal breast carcinomas.