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Endometriosis may reflect angiogenic activation.
2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Endometriosis may reflect angiogenic activation.
"Our goal in this study was to investigate the presence of angiogenesis-related factors in endometriomas by evaluating their vascular surface densities. Thirty ovarian samples were included in the study. Of these, ten were histologically confirmed endometriomas, ten were ovarian specimens in the follicular phase and ten were ovarian specimens in the luteal phase, serving as controls," researchers in Turkey reported.
"Histological specimens were immunostained for von Willebrand factor (vWF: factor VIII-related antigen) and CD34. The area with the highest microvessel density in endometriosis and in the normal ovary was evaluated by using an intercept grid," wrote S. Inan and colleagues, Celal Bayar University, School of Medicine.
"All microvessels in a specific field (x 100 magnification) were counted and vascular surface density was measured, as 164.01[+ or -]21.26 vs. 125.15[+ or -]11.28 and 117.44[+ or -]9.27 by using vWF, and as 172.97[+ or -]25.64 vs. 138.65[+ or -]32.21 and 120.34[+ or -]18.40 by using CD34 in endometriotic, follicular and luteal ovarian samples, respectively (p
"The mean vascular ...
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Source: HighBeam Research, Endometriosis may reflect angiogenic activation.