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Knowledge about basic multicellular units could prevent osteoporosis.
2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Knowledge about basic multicellular units could prevent osteoporosis.
"Bone loss at menopause is an important contributor to the development of osteoporosis in women. Although alterations in bone remodeling are the implied process through which bone is lost at menopause, how menopause influences basic multicellular units (BMUs), the teams of cells that perform bone remodeling, is not completely clear. In this analysis we utilize a computer simulation of BMU activity to evaluate the changes that occur at menopause," investigators in the United States report.
"Transient and maintained changes in both the rate of bone turnover (expressed as the BMU birthrate or origination frequency) and the focal bone balance (differences between the amount of bone formed and resorbed at each remodeling site) are considered. The magnitude of the change in BMU activity is determined parametrically through comparison to lumbar spine bone mineral density data present in the literature," stated C.J. Hernandez and colleagues, University of California Berkeley, Department of Mechanical Engineering.
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...materials are selected as they are known to induce bone formation." "Since it is known that bone turnover in basic multicellular units (BMUs) is at equilibrium, inducing an imbalance in this process via molecules known to resorb and transmit...
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...volume. For this purpose we formulate an extended bone-cell dynamics model describing functional behaviour of basic multicellular units (BMUs) responsible for bone resorption and formation. This model incorporates the RANK-RANKL-OPG signaling...
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...osteocyte cellular network has the potential to stimulate osteoclastic proliferation and therefore the activation of Basic Multicellular Units (BMUs)." Heino and colleagues published the results of their research in Technology and Health Care (Evidence...
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...loading requirements. Advancing age is associated with: (1) a reduction in the volume of bone resorbed by each basic multicellular unit (BMU); (2) an even greater reduction in the volume of bone formed by each BMU so that each remodeling...
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"During bone remodeling, bone-resorbing osteoclasts and bone-forming osteoblasts are organized in bone multicellular units (BMUs), which travel at a rate of 20-40 mu m/d for 6-12 mo, maintaining a cylindrical structure. However...
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...resorbed bone matrix can contribute to preosteoblast differentiation and bone formation. Osteoclasts in the bone multicellular units (BMUs) might also generate activity that contributes to bone formation. The preosteoblasts themselves, growing...
- Study data from University of Melbourne update understanding of bone research.
- Magazine article from: Women's Health Weekly August 27, 2009 700+ words
...loading requirements. Advancing age is associated with: (1) a reduction in the volume of bone resorbed by each basic multicellular unit (BMU); (2) an even greater reduction in the volume of bone formed by each BMU so that each remodeling...
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INTRODUCTION Trees are typically modular in structure, i.e., they are constructed of repetitive, multicellular units (Vuorisalo and Tuomi 1986). These units have been assumed to be semi-independent, especially in their carbon economy...
Source: HighBeam Research, Knowledge about basic multicellular units could prevent osteoporosis.