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Nanoparticles improve the efficacy of porphyrin in mammary tumors.
2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Nanoparticles improve the efficacy of porphyrin in mammary tumors.
"A photosensitizer, meso-tetra(hydroxyphenyl)porphyrin (p-THPP) was incorporated into sterile submicronic nanoparticles of poly(D,L-lactide-co-glycolide) (50:50 and 75:25 PLGA) and poly(D,L-lactide) (PLA). With all polymers used, sub-130 nm p-THPP-loaded nanoparticles with similar drug loadings and entrapment efficiencies were produced using the emulsification-diffusion technique. The photodynamic activity (photocytotoxicity) of these nanoparticles was evaluated on EMT-6 mammary tumor cells in comparison with the free drug," scientists in Switzerland reported.
"The influence of drug concentration (3-10 mcg/ml), incubation time (5-60 min) and light dose (6-9 J/cm(2)) on p-THPP photocytotoxic efficiency was investigated," wrote Y.N. Konan and colleagues, University of Geneva, School of Pharmacy.
"With all p-THPP formulations tested, cell viability decreased with increasing values of these parameters. The beneficial effect of nanoencapsulation compared to free drug was ...
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Source: HighBeam Research, Nanoparticles improve the efficacy of porphyrin in mammary tumors.