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Placental histology best method for pregnant women.
2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Placental histology is the best method for diagnosing malaria in pregnant women.
Researchers in Australia "compared peripheral and placental blood films (made by different techniques) with placental histology for diagnosis of Plasmodium falciparum malaria in pregnancy."
"Samples from 464 women were examined, of whom 124 (26.7%) had active P. falciparum infection and 148 (31.9%) had past infection," according to S.J. Rogerson and coauthors at the University of Melbourne.
"Placental histology was more sensitive (91%) than peripheral blood film (47%) or placental blood film (63%) examination and also detected past infection," they reported. "Few women had microscopically detectable infection without a positive histology."
"Infection detected by histology only and past infection were both associated with significantly lower infant birth weight and with lower hemoglobin concentrations compared to the results for uninfected women," study data showed.
"Thick blood films were prepared with blood obtained by placental incision or scraping of the incision margin (263 samples) or by washing of placental tissue (235 samples)," according to the report. "Each gave similar sensitivities (76% to 78%), specificities (98% to 99%), positive predictive ...
- Placental histology best method for pregnant women.
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