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Lysophosphatidic acid is an angiogenic mediator in ovarian cancer.
2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Lysophosphatidic acid is an angiogenic mediator in ovarian cancer.
According to a study from Japan, "lysophosphatidic acid (LPA) receptors including LPA(1), LPA(2), and LPA(3) mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain reaction."
"LPA2, LPA3, and VEGF expression ratios significantly increased in cancer, compared to those in non-cancerous state (p
"These results suggested that LPA2 and LPA3 may be involved in VEGF expression mediated by LPA signals in human ovarian oncogenesis," researchers concluded.
Fujita and colleagues published their study in Cancer Letters (Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid ...
- New Marker Identifies Early Ovarian Cancer.(lysophosphatidic acid measurement)
- Magazine article from: Family Practice News BRANCH, DAVID R. June 1, 1999 700+ words
...for circulating lysophosphatidic acid dramatically improves...of early-stage ovarian cancer, compared with...comparison study of lysophosphatidic acid (LPA) and cancer...10 with stage I ovarian cancer, while CA-125...
- The growth factor-like lipid lysophosphatidic acid is active in saliva.
- Newspaper article from: Immunotherapy Weekly February 26, 2003 700+ words
...recent research from Japan, "Lysophosphatidic acid is a multifunctional phospholipid...Evidence is accumulating that lysophosphatidic acid plays important physiological roles...study, we first examined whether lysophosphatidic acid is present in human saliva...
- Stereoenantiomers of lysophosphatidic acid induce proliferation or apoptosis.
- Newspaper article from: Proteomics Weekly February 17, 2003 700+ words
...cross-desensitization experiments performed with the lysophosphatidic acid (LPA) analogues (R) and (S)-N-palmitoyl-norleucinol...colleagues published their study in Biochemical Journal (A lysophosphatidic acid analogue is revealed as a potent inhibitor of phosphatidylcholine...
- Patent No. 7,608,443 Issued on Oct. 27, Assigned to E.I. du Pont de Nemours and...
- News wire article from: US Fed News Service, Including US State News October 29, 2009 700+ words
...Anthony J. Kinney of Wilmington, Del., and Rebecca E. Cahoon of Webster Groves, Mo., have developed a lysophosphatidic acid acetyltransferases. The inventors were issued U.S. Patent No. 7,608,443 on Oct. 27. The patent has...
- Researchers at National Taiwan University, Medical Department target ovarian...
- Newspaper article from: Blood Weekly October 16, 2008 700+ words
"Lysophosphatidic acid (LPA), known as the ''ovarian cancer activating factor...junction dispersal in ovarian cancer SKOV3 cells by activating...Journal of Cancer (Lysophosphatidic. acid induces ovarian cancer cell dispersal by...
- New ovarian cancer study findings have been reported by scientists at...
- Newspaper article from: Angiogenesis Weekly January 23, 2009 700+ words
...States, "Lysophosphatidic acid (LPA) acts...of human ovarian cancer increasing...treatment of ovarian cancer." Yu and...Institute (Lysophosphatidic Acid Receptors...Aggressiveness of Ovarian Cancer Cells. Journal...
- Blood tests target ovarian cancer.(Bloodwork)(Brief Article)
- Magazine article from: Medical Laboratory Observer August 1, 2004 700+ words
...accurate screening test for ovarian cancer exists. In a study recently...found that a biomarker for ovarian cancer--lysophosphatidic acid or LPA--could be used...accuracy. An LPA-based ovarian-cancer blood-screening test must...
- Atairgin Technologies to Begin Patient Enrollment with LPA Ovarian Cancer Blood...
- Press release article from: PR Newswire February 7, 2000 700+ words
...that identifies an increase in LPA, lysophosphatidic acid, present in the blood of ovarian cancer patients. Researchers believe the...to reliably detect ovarian disease. Ovarian cancer causes more deaths than any other cancer...
Source: HighBeam Research, Lysophosphatidic acid is an angiogenic mediator in ovarian cancer.