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Overexpression of KCNK9 in cell lines promotes tumor formation.

Women's Health Weekly

| June 05, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Overexpression of KCNK9 in cell lines promotes tumor formation.

"Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal region 8q24.3," scientists in the United States report.

"We examined a series of breast cancer samples harboring amplification of this region and determined that KCNK9 is the sole overexpressed gene within the amplification epicenter," wrote D. Mu and colleagues, Tularik Inc., Genomics Division.

The researchers concluded: "KCNK9 encodes a potassium channel that is amplified from 3-fold to 10-fold in 10% of breast tumors and overexpressed from 5-fold to over 100-fold in 44% of breast tumors.

"Overexpression of KCNK9 in cell lines promotes tumor ...

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