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Thymidine phosphorylase signals control the angiogenesis of ovarian cancer.
2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Thymidine phosphorylase signals control the angiogenesis of ovarian cancer.
According to recent research published in the International Journal of Oncology, "metastasis or progression of ovarian cancer cells is known to be due to the action of various angiogenic factors. We determined the expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PDECGF) and vascular endothelial growth factor (VEGF) in cell lines established from 3 serous adenocarcinomas, 3 clear cell carcinomas and 2 mucinous carcinomas of the human ovary."
"TP activity and the TP mRNA level were much higher in the serous adenocarcinoma cells than in the clear cells and mucinous carcinoma cells, and TP expression was extremely low in the clear cell carcinoma cells," reported S. Tsukagoshi and colleagues, Taiho Pharmaceutical Co. Ltd, Division of Applied Oncology.
"Expression of VEGF mRNA was variable, but not significantly different between the 3 histological types of ovarian cancer. In vivo angiogenesis in the ovarian cancer cells was evaluated by the dorsal air sac assay and revealed that SHIN-3 and HRA serous adenocarcinoma cells, which have high levels of TP expression, induced angiogenesis, while KK clear cell carcinoma cells with low TP expression, did not."
"The degree of ovarian-cancer-induced angiogenesis seemed to be independent of expression of VEGF in the cells. To confirm that the serous ...
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Source: HighBeam Research, Thymidine phosphorylase signals control the angiogenesis of ovarian...