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Super-activated interferon-regulatory factors enhance plasmid immunization.
2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Super-activated interferon-regulatory factors can enhance plasmid immunization.
According to published research from Canada, "We have been investigating the adjuvant properties of two super-activated interferon-regulatory factors (IRFs), IRF-3(5D) and IRF7/3A, identified in our previous studies of structure-function relationships, for enhancing plasmid vaccines."
"Intramuscular injection of plasmid cocktails encoding IRF-3(5D) and IRF7/3A molecules elicited cytotoxic T cell responses in over 80% of mice following a single immunization compared to a 20% response-rate using a control cocktail," said Jonathan L. Bramson and collaborators at McMaster and McGill Universities. "Most interestingly, greater than 60% of mice immunized with the super-activated IRFs developed antigen-specific antibodies compared to 0% of the mice in the control group. Finally, vaccines which incorporated the super-activated IRFs provided greater protection against challenge with a recombinant ...
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...production from macrophages." "A recombinant BCG-SM that secretes MMP-II more efficiently produced GM-CSF and activated interferon (IFN)-gamma-producing CD4(+) T cells than did vector control BCG when infected with macrophages. The...
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Source: HighBeam Research, Super-activated interferon-regulatory factors enhance plasmid...