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Naked DNA vaccine cocktail protects against lethal toxoplasmosis in mice.
2003 JUN 4 - (NewsRx.com & NewsRx.net) -- A naked DNA vaccine cocktail protected mice against a normally lethal toxoplasmosis challenge.
According to recent research published in the journal Vaccine, "BALB/c mice were intramuscularly immunized with low doses (25-50 microgram) of DNA cocktail containing plasmids encoding the full-length SAG1/P30 and the 196-561 terminal sequence of ROP2 genes."
"This immunization resulted in a Th1-type response with predominance of IgG2a and a specific T-cell proliferation with high levels of interferon-gamma (IFN-gamma) secretion, whereas no IL-4 was detected," reported Alberto Fachado and collaborators at the Oswaldo Cruz Institute, Carlos J. Finlay Institute, and Carlos G. Malbran Institute in Cuba. "Moreover, DNA cocktail immunization induced a long-lasting protection against a lethal challenge with the highly virulent Toxoplasma gondii RH strain, whereas low doses of single genes were not protective."
The researchers ...
- MERCK EXERCISES REMAINING NAKED DNA VACCINE OPTIONS.
- Press release article from: Business Wire May 1, 1995 700+ words
...license Vical's proprietary naked DNA vaccine technology for development of...strong foundation to bring our naked DNA vaccine technology to market," said...that direct administration of naked DNA can result in the expression of...
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...CTLs] in humans by a malaria DNA vaccine." The paper's senior author...Vical designed and developed the naked-DNA malaria-vaccine vector that has...antigens generated by the naked-DNA vaccine. As Hoffman informed the media...
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...scientists used the naked DNA technology to deliver...developed an experimental naked DNA vaccine to cause production...treated with a placebo DNA vaccine without the PSMA gene...immune responses) by naked DNA gene transfer to provide...
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- Magazine article from: BIOWORLD Today Leff, David N. August 9, 2000 700+ words
...titled: "Fetal immunization by a DNA vaccine delivered into the oral cavity...plasmid - a gene of double-stranded, naked DNA. It's not encapsulated in liposomes...we knew exactly where we put the DNA vaccine," he said. "So we opened the...
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- Press release article from: Business Wire May 8, 1996 700+ words
...Connaught) covering the use of Vical's proprietary ``naked'' DNA technology for DNA-based vaccine products. Pasteur...Merieux Connaught to take exclusive licenses to Vical's naked DNA vaccine technology for certain vaccine targets. Pasteur Merieux...
- Vical announces issuance of key naked DNA vaccine patent.(Vical Inc.)(Brief...
- Newspaper article from: BIOTECH Patent News April 1, 2001 700+ words
...expands the company's broad ownership of naked DNA gene delivery technologies by including administration of naked DNA into any tissue for the purpose of inducing...s previously issued patent covering naked DNA injection into muscle or skin to stimulate...
- Gun blasts naked-DNA vaccine into cell. (vaccine inoculation research on mice)...
- Magazine article from: Science News Strobel, Gabrielle January 1, 1994 700+ words
...are truly immune. "Our study is the first to demonstrate a successful vaccination of nonhuman primates using a DNA vaccine, "Weiner says. Others may quickly follow suit. Several research teams are devising similar tests in monkeys.
- Vical to Begin Collaborative Naked DNA Safety and Efficacy Vaccine Trial for...
- Press release article from: Business Wire August 22, 2000 700+ words
...of a single-gene Pf DNA vaccine, and guided dosing and...challenge trial, the MuStDO 5 DNA vaccine will include dose escalation of a naked DNA agent encoding granulocyte...development work on a naked DNA vaccine to prevent malaria, adding...
Source: HighBeam Research, Naked DNA vaccine cocktail protects against lethal toxoplasmosis in...