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Enterotoxin adjuvant protects mice against respiratory syncytial virus.
2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Immunization onto shaved skin with a bacterial enterotoxin adjuvant protected mice against respiratory syncytial virus.
"This study evaluated the potential of the skin as a non invasive route for RSV vaccination using two G protein-derived molecules, G2Na and G5 in mice. G2Na contains T and B-cell epitopes whether G5 is a pure B-cell epitope. In contrast to G5, G2Na co-administered with CT three times at one month interval onto 1 cm[superscript]2 of shaved skin, elicited a consistent serum anti-G2Na and anti-CT IgG response," scientists in France report.
"The anti-G2Na IgG response was dominated by IgG1 isotype, an indirect marker of a Th2 type of response," stated Sylvie Gaudery and collaborators at INSERM U346 and the Center d'Immunologie Pierre Fabre. "Dramatic reduction and decrease of RSV titers in lung tissues and in the nasal tract, respectively, following intranasal virus challenge revealed biological relevance of the transcutaneous immunization in the context of RSV vaccine."
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Source: HighBeam Research, Enterotoxin adjuvant protects mice against respiratory syncytial...