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Immunity to influenza boosted by H5N3 A/Duck/Singapore/97 vaccine.

Vaccine Weekly

| June 04, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Immunity to influenza H5N1 was boosted by using an MF59-adjuvanted H5N3 A/Duck/Singapore/97 vaccine in humans.

"In 1997, influenza A/Hong Kong/97 (H5N1) emerged as a potential human threat. In 1999, a randomized study comparing two doses of MF59-adjuvanted and non-adjuvanted influenza A/Duck/Singapore/97 (H5N3) surface-antigen vaccine found non-adjuvanted vaccine was poorly immunogenic. Addition of MF59 significantly boosted antibody to H5N1 to levels associated with protection," researchers in England and the Netherlands report.

"At 16 months, we undertook a follow-up study to assess the effect of H5N3 revaccination. Geometric mean titers (GMTs) of antibody by hemagglutination-inhibition (HI), microneutralization (MN), and single radial hemolysis (SRH) indicated that protective antibody titers did not exist at 16 months after two-dose priming," stated Iain Stephenson and colleagues at the Leicester Royal Infirmary and Chiron Vaccines. "Twenty-one days after revaccination, there was ...

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