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2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Immunity to influenza H5N1 was boosted by using an MF59-adjuvanted H5N3 A/Duck/Singapore/97 vaccine in humans.
"In 1997, influenza A/Hong Kong/97 (H5N1) emerged as a potential human threat. In 1999, a randomized study comparing two doses of MF59-adjuvanted and non-adjuvanted influenza A/Duck/Singapore/97 (H5N3) surface-antigen vaccine found non-adjuvanted vaccine was poorly immunogenic. Addition of MF59 significantly boosted antibody to H5N1 to levels associated with protection," researchers in England and the Netherlands report.
"At 16 months, we undertook a follow-up study to assess the effect of H5N3 revaccination. Geometric mean titers (GMTs) of antibody by hemagglutination-inhibition (HI), microneutralization (MN), and single radial hemolysis (SRH) indicated that protective antibody titers did not exist at 16 months after two-dose priming," stated Iain Stephenson and colleagues at the Leicester Royal Infirmary and Chiron Vaccines. "Twenty-one days after revaccination, there was ...