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Lipopolysaccharide not needed for T-cell response to DNA vaccination.
2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Lipopolysaccharide was not needed to induce T-cell responses to a DNA vaccine.
According to a study from the United States, "Bacterial products, including lipopolysaccharide (LPS), are potential impurities in plasmid DNA vaccines. LPS has immunostimulatory properties even at exceedingly low concentrations through activation of Toll-like receptor 4 (TLR4). The potency of T-cell responses after vaccination was tested with DNA containing high LPS or depleted of LPS in TLR4-competent and TLR4-deficient mice."
"CD8+ T-cell responses were readily induced in TLR4-deficient mice immunized with DNA depleted of LPS," reported William G. Hawkins and colleagues at the Memorial Sloan-Kettering Cancer Center in New York. "LPS in DNA ...
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Source: HighBeam Research, Lipopolysaccharide not needed for T-cell response to DNA vaccination.